| Name | Mannschaft | Zeit Einzelwertung | |||
|---|---|---|---|---|---|
| 1 |  |  | Tadej Pogačar | UAE Team Emirates | 26:36:17h |
| 2 |  |  | Wout van Aert | Team Visma / Lease a Bike | +1:03m |
| 3 |  |  | Mikel Landa | Bahrain Victorious | +3:57m |
| 4 |  |  | Egan Bernal | Ineos Grenadiers | +4:13m |
| 5 |  |  | Matteo Fabbro | Red Bull–Bora–Hansgrohe | +4:37m |
| 6 |  |  | João Almeida | Soudal - Quick Step | +4:54m |
| 7 |  | | Tim Wellens | Lotto–Dstny | +5:00m |
| 8 |  |  | Romain Bardet | Team dsm-firmenich PostNL | +5:50m |
| 9 |  | | Vincenzo Nibali | Lidl - Trek | +6:30m |
| 10 |  |  | Simon Yates | Team Jayco AlUla | +7:45m |
| Wettbewerb | Wettbewerb | Datum | Sieger | ||
|---|---|---|---|---|---|
 | UAE Tour | UAE Tour | 27.02.2021 | T. Pogačar | |
| Omloop Het Nieuwsblad | Omloop Het Nieuwsblad | 27.02.2021 | D. Ballerini | |
| Strade Bianche | Strade Bianche | 06.03.2021 | M. Van der Poel | |
| Paris-Nice | Paris-Nice | 14.03.2021 | M. Schachmann | |
| Tirreno-Adriatico | Tirreno-Adriatico | 16.03.2021 | T. Pogačar | |
| Milano-Sanremo | Milano-Sanremo | 20.03.2021 | J. Stuyven | |
| Volta Ciclista a Catalunya | Volta Ciclista a Catalunya | 27.03.2021 | A. Yates | |
| Driedaagse Brugge-De Panne | Driedaagse | 24.03.2021 | S. Bennett | |
| E3 Harelbeke | E3 Harelbeke | 26.03.2021 | K. Asgreen | |
| Gent-Wevelgem | Gent-Wevelgem | 28.03.2021 | W. van Aert | |
| Dwars door Vlaanderen | Dwars door Vlaanderen | 31.03.2021 | D. van Baarle | |
| Ronde van Vlaanderen | Ronde van Vlaanderen | 04.04.2021 | K. Asgreen | |
| Vuelta Ciclista al País Vasco | Vuelta Ciclista al País Vasco | 10.04.2021 | P. Roglič | |
 | Amstel Gold Race | Amstel Gold Race | 18.04.2021 | W. van Aert | |
| La Flèche Wallonne | La Flèche Wallonne | 21.04.2021 | J. Alaphilippe | |
| Liège-Bastogne-Liège | Liège-Bastogne-Liège | 25.04.2021 | T. Pogačar | |
 | Tour de Romandie | Tour de Romandie | 02.05.2021 | G. Thomas | |
| Giro d'Italia | Giro d'Italia | 30.05.2021 | E. Bernal | |
| Critérium du Dauphiné | Critérium du Dauphiné | 06.06.2021 | R. Porte | |
| Tour de Suisse | Tour de Suisse | 13.06.2021 | R. Carapaz | |
| Tour de France | Tour de France | 18.07.2021 | T. Pogačar | |
| Clásica San Sebastián | Clásica San Sebastián | 31.07.2021 | N. Powless | |
 | Tour de Pologne | Tour de Pologne | 15.08.2021 | J. Almeida | |
| Vuelta a España | Vuelta a España | 05.09.2021 | P. Roglič | |
 | Deutschland Tour | Deutschland Tour | 29.08.2021 | N. Politt | |
| Bretagne Classic – Ouest-France | GP Ouest France | 29.08.2021 | B. Cosnefroy | |
| Benelux Tour | Benelux Tour | 05.09.2021 | S. Colbrelli | ||
| Eschborn-Frankfurt | Eschborn-Frankfurt | 19.09.2021 | J. Philipsen | |
| Paris-Roubaix | Paris-Roubaix | 03.10.2021 | S. Colbrelli | |
| Il Lombardia | Il Lombardia | 09.10.2021 | T. Pogačar |
