| # | Nom | Équipe | Buts | Pén | |
|---|---|---|---|---|---|
| 1 |  | Cristiano Ronaldo | Real Madrid | 48 | 10 |
| 2 |  | Lionel Messi | FC Barcelone | 43 | 5 |
| 3 |  | Antoine Griezmann | Atlético de Madrid | 22 | 0 |
| Neymar | FC Barcelone | 22 | 1 | |
| 5 |  | Carlos Bacca | Séville FC | 20 | 6 |
| 6 |  | Aduriz | Athletic Club | 18 | 5 |
| 7 |  | Bueno | Rayo Vallecano | 17 | 2 |
| 8 | | Luis Suárez | FC Barcelone | 16 | 0 |
| 9 | | Karim Benzema | Real Madrid | 15 | 0 |
| 10 |  | Jonathas | Elche CF | 14 | 0 |
 | Sergio García | Espanyol Barcelona | 14 | 2 | |
| 12 | | Gareth Bale | Real Madrid | 13 | 1 |
 | Nolito | RC Celta | 13 | 3 | |
| James Rodríguez | Real Madrid | 13 | 0 | |
| 15 |  | Dani Parejo | Valence CF | 12 | 3 |
| Mario Mandžukić | Atlético de Madrid | 12 | 3 | |
| Cristhian Stuani | Espanyol Barcelona | 12 | 2 | |
 | Luciano Vietto | Villarreal CF | 12 | 0 | |
| 19 |  | Barral | Levante UD | 11 | 2 |
| Joaquín Larrivey | RC Celta | 11 | 0 | |
| Paco Alcácer | Valence CF | 11 | 0 | |
| 22 |  | Arruabarrena | SD Eibar | 9 | 2 |
| Felipe Caicedo | Espanyol Barcelona | 9 | 0 | |
 | Carlos Vela | Real Sociedad | 9 | 1 | |
| 25 |  | Youssef El-Arabi | Granada CF | 8 | 4 |
| Kevin Gameiro | Séville FC | 8 | 2 | |
 | Tomer Hemed | UD Almería | 8 | 2 | |
 | Juanmi | Málaga CF | 8 | 0 | |
| Víctor Casadesús | Levante UD | 8 | 0 | |
| 30 | | Agirretxe | Real Sociedad | 7 | 0 |
 | Álvaro | Getafe CF | 7 | 1 | |
| Gerard Moreno | Villarreal CF | 7 | 0 | |
 | Nabil Ghilas | Córdoba CF | 7 | 2 | |
| Javier Hernández | Real Madrid | 7 | 0 | |
| Iborra | Séville FC | 7 | 0 | |
| Leo Baptistão | Atlético de Madrid | 7 | 0 | |
| Pablo Piatti | Valence CF | 7 | 0 | |
| Santi Mina | RC Celta | 7 | 1 | |
| 39 | | Nordin Amrabat | Málaga CF | 6 | 3 |
| Sofiane Féghouli | Valence CF | 6 | 0 | |
 | Lucas Pérez | Deportivo La Coruña | 6 | 1 | |
| Nicolás Otamendi | Valence CF | 6 | 0 | |
| Pedro | FC Barcelone | 6 | 0 | |
| Federico Piovaccari | SD Eibar | 6 | 0 | |
| Ikechukwu Uche | Villarreal CF | 6 | 1 | |
| Vitolo | Séville FC | 6 | 0 | |
| 47 | | Álvaro Negredo | Valence CF | 5 | 1 |
| Florin Andone | Córdoba CF | 5 | 0 | |
| Javi Guerra | Málaga CF | 5 | 0 | |
| Gaël Kakuta | Rayo Vallecano | 5 | 0 | |
| Lombán | Elche CF | 5 | 3 | |
| Manucho | Rayo Vallecano | 5 | 0 | |
| Mikel San José | Athletic Club | 5 | 0 | |
| Fabián Orellana | RC Celta | 5 | 0 | |
| Piqué | FC Barcelone | 5 | 0 | |
| Ivan Rakitić | FC Barcelone | 5 | 0 | |
| Raúl García | Atlético de Madrid | 5 | 2 | |
| Rober Ibáñez | Granada CF | 5 | 0 | |
| Samuel | Málaga CF | 5 | 0 | |
| Tiago | Atlético de Madrid | 5 | 0 | |
| Kalu Uche | Levante UD | 5 | 0 | |
| 62 | | Aleix Vidal | Séville FC | 4 | 0 |
| André Gomes | Valence CF | 4 | 0 | |
| Thievy Bifouma | Espanyol Barcelona | 4 | 0 | |
| Federico Cartabia | Córdoba CF | 4 | 0 | |
| Gonzalo Castro | Real Sociedad | 4 | 0 | |
| Denis Cheryshev | Villarreal CF | 4 | 0 | |
| Jhon Córdoba | Espanyol Barcelona | 4 | 0 | |
| Édgar Méndez | UD Almería | 4 | 0 | |
| Isco | Real Madrid | 4 | 0 | |
| Stéphane M'bia | Séville FC | 4 | 0 | |
| Moi Gómez | Villarreal CF | 4 | 0 | |
| Shkodran Mustafi | Valence CF | 4 | 0 | |
| Oriol Riera | Deportivo La Coruña | 4 | 0 | |
| Thomas Partey | UD Almería | 4 | 0 | |
| Saúl Ñíguez | Atlético de Madrid | 4 | 0 | |
| Sergi Darder | Málaga CF | 4 | 0 | |
| Sergio Canales | Real Sociedad | 4 | 0 | |
| Sergio Ramos | Real Madrid | 4 | 0 | |
| Toché | Deportivo La Coruña | 4 | 0 | |
| Verza | UD Almería | 4 | 3 | |
| Víctor | Elche CF | 4 | 0 | |
| Xabi Prieto | Real Sociedad | 4 | 2 | |
| Abdoul Yoda | Getafe CF | 4 | 0 | |
| 85 | | Adrián Embarba | Rayo Vallecano | 3 | 0 |
| Éver Banega | Séville FC | 3 | 0 | |
| Celso Borges | Deportivo La Coruña | 3 | 1 | |
| Capa | SD Eibar | 3 | 0 | |
| Charles | RC Celta | 3 | 0 | |
| Diego Castro | Getafe CF | 3 | 0 | |
| Edu Albácar | Elche CF | 3 | 1 | |
| Fernando Torres | Atlético de Madrid | 3 | 0 | |
| Fran Rico | Granada CF | 3 | 2 | |
| Diego Godín | Atlético de Madrid | 3 | 0 | |
| Ivan Cavaleiro | Deportivo La Coruña | 3 | 0 | |
| Javi Fuego | Valence CF | 3 | 0 | |
| Jesé | Real Madrid | 3 | 0 | |
| José Morales | Levante UD | 3 | 0 | |
| Lucas Vázquez | Espanyol Barcelona | 3 | 0 | |
| Mainz | Granada CF | 3 | 0 | |
| Manu del Moral | Elche CF | 3 | 0 | |
| Mario Gaspar | Villarreal CF | 3 | 0 | |
| Mikel Rico | Athletic Club | 3 | 0 | |
| Miranda | Atlético de Madrid | 3 | 0 | |
| Mateo Musacchio | Villarreal CF | 3 | 0 | |
| Mario Pašalić | Elche CF | 3 | 0 | |
| Reyes | Séville FC | 3 | 0 | |
| Rodrigo | Valence CF | 3 | 1 | |
| Roque Santa Cruz | Málaga CF | 3 | 0 | |
| Saúl Berjón | SD Eibar | 3 | 0 | |
| Soriano | UD Almería | 3 | 0 | |
| Víctor Sánchez | Espanyol Barcelona | 3 | 0 | |
| 113 | | Beñat | Athletic Club | 2 | 0 |
| Bruno Soriano | Villarreal CF | 2 | 1 | |
| Camacho | Málaga CF | 2 | 0 | |
| Coke | Séville FC | 2 | 0 | |
| Denis Suárez | Séville FC | 2 | 0 | |
| Jonathan Dos Santos | FC Barcelone | 2 | 0 | |
| Etxeita | Athletic Club | 2 | 0 | |
| Nicolás Fedor | Rayo Vallecano | 2 | 0 | |
| Alfreð Finnbogason | Real Sociedad | 2 | 0 | |
| Pablo Hernández | RC Celta | 2 | 0 | |
| Fredy Hinestroza | Getafe CF | 2 | 0 | |
| Iago Aspas | Séville FC | 2 | 0 | |
| Iñigo Martínez | Real Sociedad | 2 | 0 | |
| Isaac Cuenca | Deportivo La Coruña | 2 | 1 | |
| Iturraspe | Athletic Club | 2 | 0 | |
| Javi Espinosa | UD Almería | 2 | 0 | |
| José Rodríguez | Deportivo La Coruña | 2 | 0 | |
| Koke | Atlético de Madrid | 2 | 0 | |
| Toni Kroos | Real Madrid | 2 | 0 | |
| Grzegorz Krychowiak | Séville FC | 2 | 0 | |
| Mehdi Lacen | Getafe CF | 2 | 0 | |
| Lafita | Getafe CF | 2 | 0 | |
| Lopo García | Deportivo La Coruña | 2 | 0 | |
| Luis Alberto | Málaga CF | 2 | 0 | |
| Marcelo | Real Madrid | 2 | 0 | |
| Jérémy Mathieu | FC Barcelone | 2 | 0 | |
| Haris Medunjanin | Deportivo La Coruña | 2 | 1 | |
| Michel Macedo | UD Almería | 2 | 0 | |
| Pablo Sarabia | Getafe CF | 2 | 0 | |
| Pedro León | Getafe CF | 2 | 0 | |
| Pepe | Real Madrid | 2 | 0 | |
| Raúl Albentosa | SD Eibar | 2 | 0 | |
| Raúl Baena | Rayo Vallecano | 2 | 0 | |
| Raúl Navas | Real Sociedad | 2 | 0 | |
| Garry Rodrigues | Elche CF | 2 | 0 | |
| Rubén Rochina | Granada CF | 2 | 0 | |
| Sandro | FC Barcelone | 2 | 0 | |
| Sergio Escudero | Getafe CF | 2 | 0 | |
| Arda Turan | Atlético de Madrid | 2 | 0 | |
| Víctor Camarasa | Levante UD | 2 | 0 | |
| Xavi | FC Barcelone | 2 | 0 | |
| Jonathan Zongo | UD Almería | 2 | 0 | |
| David Zurutuza | Real Sociedad | 2 | 0 | |
| 156 | | Abraham | Espanyol Barcelona | 1 | 0 |
| Abraham | SD Eibar | 1 | 0 | |
| Aketxe | Athletic Club | 1 | 0 | |
| Álex López | RC Celta | 1 | 0 | |
| Alexis | Getafe CF | 1 | 0 | |
| Álvaro González | Espanyol Barcelona | 1 | 0 | |
| Amaya | Rayo Vallecano | 1 | 0 | |
| Antunes | Málaga CF | 1 | 1 | |
| Arbeloa | Real Madrid | 1 | 0 | |
| Arbilla | Espanyol Barcelona | 1 | 0 | |
| Aritz Elustondo | Real Sociedad | 1 | 0 | |
| Jean-Sylvain Babin | Granada CF | 1 | 0 | |
| Barragán | Valence CF | 1 | 0 | |
| Théo Bongonda | RC Celta | 1 | 0 | |
| Borja Fernández | SD Eibar | 1 | 0 | |
| Borja García | Córdoba CF | 1 | 0 | |
| Busquets | FC Barcelone | 1 | 0 | |
| Gustavo Cabral | RC Celta | 1 | 0 | |
| Joel Campbell | Villarreal CF | 1 | 0 | |
| Carles Gil | Valence CF | 1 | 0 | |
| Diego Colotto | Espanyol Barcelona | 1 | 0 | |
| Cristian Herrera | Elche CF | 1 | 0 | |
| Dani García | SD Eibar | 1 | 0 | |
| Daniel Carriço | Séville FC | 1 | 0 | |
| De la Bella | Real Sociedad | 1 | 0 | |
| De Marcos | Athletic Club | 1 | 0 | |
| Rodrigo De Paul | Valence CF | 1 | 0 | |
| Babá Diawara | Getafe CF | 1 | 0 | |
| Diogo Figueiras | Séville FC | 1 | 0 | |
| Diogo Salomão | Deportivo La Coruña | 1 | 0 | |
| Giovani dos Santos | Villarreal CF | 1 | 0 | |
| Mauro Dos Santos | UD Almería | 1 | 0 | |
| Duda | Málaga CF | 1 | 0 | |
| Patrick Ekeng | Córdoba CF | 1 | 0 | |
| Nabil El Zhar | Levante UD | 1 | 0 | |
| Elustondo | Real Sociedad | 1 | 0 | |
| Eneko Bóveda | SD Eibar | 1 | 0 | |
| Fayçal Fajr | Elche CF | 1 | 0 | |
| Luis Fariña | Deportivo La Coruña | 1 | 0 | |
| Augusto Fernández | RC Celta | 1 | 0 | |
| Fidel | Córdoba CF | 1 | 0 | |
| Gayà | Valence CF | 1 | 0 | |
| Gerard Deulofeu | FC Barcelone | 1 | 0 | |
| José Giménez | Atlético de Madrid | 1 | 0 | |
| Gurpegi | Athletic Club | 1 | 0 | |
| Hélder Postiga | Deportivo La Coruña | 1 | 0 | |
| Hugo Mallo | RC Celta | 1 | 0 | |
| Ibai | Athletic Club | 1 | 0 | |
| Iñaki Williams | Athletic Club | 1 | 0 | |
| Emiliano Insúa | Atlético de Madrid | 1 | 0 | |
| Andoni Iraola | Athletic Club | 1 | 0 | |
| Andreas Ivanschitz | Levante UD | 1 | 1 | |
| Jaume Costa | Villarreal CF | 1 | 0 | |
| Javi Lara | SD Eibar | 1 | 0 | |
| Raúl Jiménez | Atlético de Madrid | 1 | 0 | |
| Jordi Alba | FC Barcelone | 1 | 0 | |
| Jorge Morcillo | Rayo Vallecano | 1 | 0 | |
| Jorge Sammir | Getafe CF | 1 | 0 | |
| Jozabed | Rayo Vallecano | 1 | 0 | |
| Juan Domínguez | Deportivo La Coruña | 1 | 0 | |
| Juan Rodríguez | Getafe CF | 1 | 0 | |
| Juanfran | Deportivo La Coruña | 1 | 0 | |
| Timothée Kolodziejczak | Séville FC | 1 | 0 | |
| Michael Krohn-Dehli | RC Celta | 1 | 0 | |
| Luso | Córdoba CF | 1 | 0 | |
| Marc Bartra | FC Barcelone | 1 | 0 | |
| Mario Suárez | Atlético de Madrid | 1 | 0 | |
| Markel Bergara | Real Sociedad | 1 | 0 | |
| Markel Susaeta | Athletic Club | 1 | 0 | |
| Míchel | Getafe CF | 1 | 0 | |
| Luka Modrić | Real Madrid | 1 | 0 | |
| Héctor Moreno | Espanyol Barcelona | 1 | 0 | |
| Mosquera | Elche CF | 1 | 0 | |
| Muniain | Athletic Club | 1 | 0 | |
| Munir | FC Barcelone | 1 | 0 | |
| Nacho | Real Madrid | 1 | 0 | |
| Allan Nyom | Granada CF | 1 | 0 | |
| Lucas Orbán | Valence CF | 1 | 0 | |
| Pablo Hervías | Real Sociedad | 1 | 0 | |
| Paco Montañés | Espanyol Barcelona | 1 | 0 | |
| Nicolás Pareja | Séville FC | 1 | 0 | |
| Piti | Granada CF | 1 | 0 | |
| Rafael | Levante UD | 1 | 0 | |
| Rafinha | FC Barcelone | 1 | 0 | |
| Recio | Málaga CF | 1 | 0 | |
| Ricardo Horta | Málaga CF | 1 | 0 | |
| Rubén García | Levante UD | 1 | 0 | |
| Rubén Pardo | Real Sociedad | 1 | 0 | |
| Samu Castillejo | Málaga CF | 1 | 0 | |
| Simão | Levante UD | 1 | 0 | |
| Siqueira | Atlético de Madrid | 1 | 0 | |
| Damián Suárez | Elche CF | 1 | 0 | |
| Isaac Success | Granada CF | 1 | 0 | |
| Trashorras | Rayo Vallecano | 1 | 0 | |
| Trigueros | Villarreal CF | 1 | 0 | |
| Emiliano Velázquez | Atlético de Madrid | 1 | 0 | |
| Viguera | Athletic Club | 1 | 0 | |
| Xisco | Córdoba CF | 1 | 0 |
