| # | Nom | Équipe | Buts | Pén | |
|---|---|---|---|---|---|
| 1 |  | Luis Suárez | FC Barcelone | 40 | 3 |
| 2 |  | Cristiano Ronaldo | Real Madrid | 35 | 6 |
| 3 | | Lionel Messi | FC Barcelone | 26 | 3 |
| 4 | | Karim Benzema | Real Madrid | 24 | 0 |
| Neymar | FC Barcelone | 24 | 5 | |
| 6 |  | Antoine Griezmann | Atlético de Madrid | 22 | 1 |
| 7 |  | Aduriz | Athletic Bilbao | 20 | 3 |
| 8 | | Gareth Bale | Real Madrid | 19 | 0 |
 | Rubén Castro | Betis Séville | 19 | 3 | |
| 10 | | Borja Bastón | Atlético de Madrid | 18 | 3 |
| 11 |  | Lucas Pérez | Deportivo La Coruña | 17 | 1 |
| 12 |  | Youssef El-Arabi | Granada CF | 16 | 7 |
 | Kevin Gameiro | Séville FC | 16 | 4 | |
| 14 |  | Iago Aspas | RC Celta | 14 | 1 |
| 15 |  | Agirretxe | Real Sociedad | 13 | 0 |
 | Paco Alcácer | Valence CF | 13 | 2 | |
| 17 |  | Cédric Bakambu | Villarreal CF | 12 | 0 |
 | Charles | Málaga CF | 12 | 1 | |
 | Javi Guerra | Rayo Vallecano | 12 | 0 | |
| Nolito | RC Celta | 12 | 1 | |
| 21 | | Fernando Torres | Atlético de Madrid | 11 | 0 |
 | Antonio Sanabria | Sporting Gijón | 11 | 1 | |
| 23 |  | Jonathan Viera | UD Las Palmas | 10 | 4 |
| 24 |  | Deyverson | Levante UD | 9 | 0 |
| Miku Fedor | Rayo Vallecano | 9 | 0 | |
| Jozabed | Rayo Vallecano | 9 | 0 | |
 | Sergi Enrich | SD Eibar | 9 | 0 | |
| Willian José | UD Las Palmas | 9 | 0 | |
| 29 |  | Felipe Caicedo | Espanyol Barcelona | 8 | 0 |
| Dani Parejo | Valence CF | 8 | 2 | |
| Iñaki Williams | Athletic Bilbao | 8 | 0 | |
| 32 | | Carlos Castro | Sporting Gijón | 7 | 0 |
| Duje Čop | Málaga CF | 7 | 1 | |
| Gerard Moreno | Espanyol Barcelona | 7 | 1 | |
| John Guidetti | RC Celta | 7 | 1 | |
| Vicente Iborra | Séville FC | 7 | 0 | |
| Jonathas | Real Sociedad | 7 | 0 | |
| José Morales | Levante UD | 7 | 0 | |
| Fabián Orellana | RC Celta | 7 | 1 | |
 | Pablo Sarabia | Getafe CF | 7 | 0 | |
| Hernán Pérez | Espanyol Barcelona | 7 | 0 | |
| Ivan Rakitić | FC Barcelone | 7 | 0 | |
| Raúl García | Athletic Bilbao | 7 | 0 | |
| James Rodríguez | Real Madrid | 7 | 0 | |
| 45 | | Luis Alberto | Deportivo La Coruña | 6 | 0 |
| Mikel Oyarzabal | Real Sociedad | 6 | 0 | |
| Giuseppe Rossi | Levante UD | 6 | 1 | |
| Rubén Rochina | Granada CF | 6 | 0 | |
| Stefan Šćepović | Getafe CF | 6 | 0 | |
| Isaac Success | Granada CF | 6 | 0 | |
| 51 | | Álvaro | Getafe CF | 5 | 1 |
| Álvaro Negredo | Valence CF | 5 | 0 | |
| Sergio Araujo | UD Las Palmas | 5 | 0 | |
| Éver Banega | Séville FC | 5 | 1 | |
| Bruno Soriano | Villarreal CF | 5 | 3 | |
| Ángel Correa | Atlético de Madrid | 5 | 0 | |
| Fayçal Fajr | Deportivo La Coruña | 5 | 0 | |
| Jesé | Real Madrid | 5 | 0 | |
| Jony | Sporting Gijón | 5 | 0 | |
| Koke | Atlético de Madrid | 5 | 0 | |
| Adalberto Peñaranda | Granada CF | 5 | 0 | |
| Sabin | Athletic Bilbao | 5 | 0 | |
| Soldado | Villarreal CF | 5 | 0 | |
| Tana | UD Las Palmas | 5 | 0 | |
| Carlos Vela | Real Sociedad | 5 | 0 | |
| 66 | | Adrián | Villarreal CF | 4 | 0 |
| Adrián | SD Eibar | 4 | 0 | |
| Yannick Carrasco | Atlético de Madrid | 4 | 0 | |
| Denis Suárez | Séville FC | 4 | 0 | |
| Juanpi | Málaga CF | 4 | 0 | |
| Yevgen Konoplyanka | Séville FC | 4 | 1 | |
| Llorente | Séville FC | 4 | 0 | |
| Lucas Vázquez | Espanyol Barcelona | 4 | 0 | |
| Manucho | Rayo Vallecano | 4 | 0 | |
| Marco Asensio | Espanyol Barcelona | 4 | 0 | |
| Santi Mina | RC Celta | 4 | 0 | |
| Saúl | Atlético de Madrid | 4 | 0 | |
| Saúl Berjón | SD Eibar | 4 | 3 | |
| 79 | | Jean-Sylvain Babin | Granada CF | 3 | 0 |
| Bebé | Rayo Vallecano | 3 | 0 | |
| Bigas | UD Las Palmas | 3 | 0 | |
| Celso Borges | Deportivo La Coruña | 3 | 0 | |
| Federico Cartabia | Deportivo La Coruña | 3 | 0 | |
| Denis Cheryshev | Real Madrid | 3 | 0 | |
| Pape Diop | Espanyol Barcelona | 3 | 0 | |
| Gonzalo Escalante | SD Eibar | 3 | 0 | |
| Alen Halilović | FC Barcelone | 3 | 0 | |
| Takashi Inui | SD Eibar | 3 | 0 | |
| Isco | Real Madrid | 3 | 0 | |
| Keko | SD Eibar | 3 | 0 | |
| Lafita | Getafe CF | 3 | 0 | |
| Aymeric Laporte | Athletic Bilbao | 3 | 0 | |
| Leo Baptistão | Villarreal CF | 3 | 0 | |
| Markel Susaeta | Athletic Bilbao | 3 | 0 | |
| Munir | FC Barcelone | 3 | 0 | |
| Steven Nzonzi | Séville FC | 3 | 0 | |
| Pablo Hernández | Rayo Vallecano | 3 | 0 | |
| Germán Pezzella | Betis Séville | 3 | 0 | |
| Trashorras | Rayo Vallecano | 3 | 2 | |
| Emiliano Velázquez | Getafe CF | 3 | 0 | |
| Víctor Casadesús | Levante UD | 3 | 0 | |
| Xabi Prieto | Real Sociedad | 3 | 1 | |
| 103 | | Adrián Embarba | Rayo Vallecano | 2 | 0 |
| Álex Bergantiños | Deportivo La Coruña | 2 | 0 | |
| Álex Menéndez | Sporting Gijón | 2 | 0 | |
| André Gomes | Valence CF | 2 | 0 | |
| Alejandro Arribas | Deportivo La Coruña | 2 | 0 | |
| Christian Atsu | Málaga CF | 2 | 0 | |
| Théo Bongonda | RC Celta | 2 | 0 | |
| Bruma | Real Sociedad | 2 | 0 | |
| Camacho | Málaga CF | 2 | 0 | |
| Capa | SD Eibar | 2 | 0 | |
| Carmona | Sporting Gijón | 2 | 0 | |
| Danilo | Real Madrid | 2 | 0 | |
| David García | UD Las Palmas | 2 | 0 | |
| Nabil El Zhar | Levante UD | 2 | 0 | |
| Eraso | Athletic Bilbao | 2 | 0 | |
| Fran Rico | Granada CF | 2 | 0 | |
| Guerrero | Sporting Gijón | 2 | 0 | |
| Pablo Hernández | RC Celta | 2 | 0 | |
| Ciro Immobile | Séville FC | 2 | 0 | |
| Isaac Cuenca | Deportivo La Coruña | 2 | 0 | |
| Isma López | Sporting Gijón | 2 | 0 | |
| Llorente | Rayo Vallecano | 2 | 0 | |
| Marc Bartra | FC Barcelone | 2 | 0 | |
| Marcelo | Real Madrid | 2 | 0 | |
| Mario Gaspar | Villarreal CF | 2 | 0 | |
| Jackson Martínez | Atlético de Madrid | 2 | 0 | |
| Medrán | Getafe CF | 2 | 0 | |
| Mikel San José | Athletic Bilbao | 2 | 0 | |
| Luka Modrić | Real Madrid | 2 | 0 | |
| Moi Gómez | Getafe CF | 2 | 0 | |
| Muniain | Athletic Bilbao | 2 | 0 | |
| Shkodran Mustafi | Valence CF | 2 | 0 | |
| Alfred N'Diaye | Betis Séville | 2 | 0 | |
| Oriol Riera | Deportivo La Coruña | 2 | 0 | |
| Thomas Partey | Atlético de Madrid | 2 | 0 | |
| Pedro León | Getafe CF | 2 | 0 | |
| Piqué | FC Barcelone | 2 | 0 | |
| Piti | Granada CF | 2 | 0 | |
| Raúl Albentosa | Málaga CF | 2 | 0 | |
| Diego Reyes | Real Sociedad | 2 | 0 | |
| Enzo Roco | Espanyol Barcelona | 2 | 0 | |
| Rodrigo | Valence CF | 2 | 0 | |
| Samuel | Villarreal CF | 2 | 0 | |
| Roque Santa Cruz | Málaga CF | 2 | 0 | |
| Sergio Álvarez | Sporting Gijón | 2 | 0 | |
| Sergio Ramos | Real Madrid | 2 | 0 | |
| Trigueros | Villarreal CF | 2 | 0 | |
| Arda Turan | Atlético de Madrid | 2 | 0 | |
| Juan Vargas | Betis Séville | 2 | 0 | |
| Verza | Levante UD | 2 | 1 | |
| Víctor | Getafe CF | 2 | 0 | |
| Víctor Camarasa | Levante UD | 2 | 0 | |
| Vitolo | Séville FC | 2 | 0 | |
| Daniel Wass | RC Celta | 2 | 0 | |
| Zé Castro | Rayo Vallecano | 2 | 0 | |
| 158 | | Abraham | Espanyol Barcelona | 1 | 0 |
| Antolín Alcaráz | UD Las Palmas | 1 | 0 | |
| Alexis | Getafe CF | 1 | 0 | |
| Víctor Álvarez | Espanyol Barcelona | 1 | 0 | |
| Álvaro Cejudo | Betis Séville | 1 | 0 | |
| Amaya | Rayo Vallecano | 1 | 0 | |
| Aritz Elustondo | Real Sociedad | 1 | 0 | |
| Arruabarrena | SD Eibar | 1 | 0 | |
| Zakaria Bakkali | Valence CF | 1 | 0 | |
| Claudio Beauvue | RC Celta | 1 | 0 | |
| Beñat | Athletic Bilbao | 1 | 0 | |
| Emiliano Buendia | Getafe CF | 1 | 0 | |
| Burgui | Espanyol Barcelona | 1 | 0 | |
| Cala | Getafe CF | 1 | 0 | |
| Casemiro | Real Madrid | 1 | 0 | |
| Gonzalo Castro | Málaga CF | 1 | 0 | |
| Coke | Séville FC | 1 | 0 | |
| Daniel Carriço | Séville FC | 1 | 0 | |
| David Simón | UD Las Palmas | 1 | 0 | |
| De Marcos | Athletic Bilbao | 1 | 0 | |
| Diego González | Séville FC | 1 | 0 | |
| Óscar Duarte | Espanyol Barcelona | 1 | 0 | |
| Duda | Málaga CF | 1 | 0 | |
| Édgar Méndez | Granada CF | 1 | 0 | |
| Elustondo | Athletic Bilbao | 1 | 0 | |
| Sergio Escudero | Getafe CF | 1 | 0 | |
| Bernardo Espinosa | Sporting Gijón | 1 | 0 | |
| Zouhair Feddal | Levante UD | 1 | 0 | |
| Sofiane Féghouli | Valence CF | 1 | 0 | |
| Augusto Fernández | Atlético de Madrid | 1 | 0 | |
| Filipe Luís | Atlético de Madrid | 1 | 0 | |
| Fontàs | RC Celta | 1 | 0 | |
| Dimitri Foulquier | Granada CF | 1 | 0 | |
| Gabi | Atlético de Madrid | 1 | 0 | |
| José Giménez | Atlético de Madrid | 1 | 0 | |
| Diego Godín | Atlético de Madrid | 1 | 0 | |
| Hernán | UD Las Palmas | 1 | 0 | |
| Hugo Mallo | RC Celta | 1 | 0 | |
| Illarramendi | Real Madrid | 1 | 0 | |
| Iniesta | FC Barcelone | 1 | 0 | |
| Iñigo Lekue | Athletic Bilbao | 1 | 0 | |
| Iñigo Martínez | Real Sociedad | 1 | 0 | |
| Jaume Costa | Villarreal CF | 1 | 0 | |
| Joan Jordán | Espanyol Barcelona | 1 | 0 | |
| João Cancelo | Valence CF | 1 | 0 | |
| Joaquín | Betis Séville | 1 | 0 | |
| Jon Bautista | Real Sociedad | 1 | 0 | |
| Jonny | RC Celta | 1 | 0 | |
| Jorge Molina | Betis Séville | 1 | 0 | |
| Juan Muñoz | Séville FC | 1 | 0 | |
| Juanfran | Atlético de Madrid | 1 | 0 | |
| Juanfran | Deportivo La Coruña | 1 | 0 | |
| Juankar | Málaga CF | 1 | 0 | |
| Michael Krohn-Dehli | Séville FC | 1 | 0 | |
| Toni Kroos | Real Madrid | 1 | 0 | |
| Jefferson Lerma | Levante UD | 1 | 0 | |
| Markel Bergara | Real Sociedad | 1 | 0 | |
| Carl Medjani | Levante UD | 1 | 0 | |
| Mikel Rico | Athletic Bilbao | 1 | 0 | |
| Mateo Musacchio | Villarreal CF | 1 | 0 | |
| Charly Musonda | Betis Séville | 1 | 0 | |
| Dani N'Di | Sporting Gijón | 1 | 0 | |
| Nacho Cases | Sporting Gijón | 1 | 0 | |
| Pablo Fornals | Málaga CF | 1 | 0 | |
| Pedro López | Levante UD | 1 | 0 | |
| Pepe | Real Madrid | 1 | 0 | |
| Petros | Betis Séville | 1 | 0 | |
| Rafinha | FC Barcelone | 1 | 0 | |
| Raúl Baena | Rayo Vallecano | 1 | 0 | |
| Vincenzo Rennella | Betis Séville | 1 | 0 | |
| Reyes | Séville FC | 1 | 0 | |
| Ricardo Costa | Granada CF | 1 | 0 | |
| Federico Ricca | Málaga CF | 1 | 0 | |
| Roque Mesa | UD Las Palmas | 1 | 0 | |
| Rubén García | Levante UD | 1 | 0 | |
| Salva Sevilla | Espanyol Barcelona | 1 | 0 | |
| Samu Castillejo | Villarreal CF | 1 | 0 | |
| Simão | Levante UD | 1 | 0 | |
| Tiago | Atlético de Madrid | 1 | 0 | |
| Adnane Tighadouini | Málaga CF | 1 | 0 | |
| Tito | Rayo Vallecano | 1 | 0 | |
| Ricky van Wolfswinkel | Betis Séville | 1 | 0 | |
| Verdú | Levante UD | 1 | 0 | |
| Thomas Vermaelen | FC Barcelone | 1 | 0 | |
| Vicente Gómez | UD Las Palmas | 1 | 0 | |
| Víctor Sánchez | Espanyol Barcelona | 1 | 0 | |
| Luciano Vietto | Atlético de Madrid | 1 | 0 | |
| Vigaray | Getafe CF | 1 | 0 | |
| Mubarak Wakaso | UD Las Palmas | 1 | 0 | |
| Heiko Westermann | Betis Séville | 1 | 0 | |
| David Zurutuza | Real Sociedad | 1 | 0 |
