| # | Nom | Équipe | Buts | Pén | |
|---|---|---|---|---|---|
| 1 |  | Lionel Messi | FC Barcelone | 34 | 2 |
| 2 |  | Cristiano Ronaldo | Real Madrid | 26 | 3 |
| 3 | | Luis Suárez | FC Barcelone | 25 | 1 |
| 4 |  | Iago Aspas | RC Celta | 22 | 2 |
| 5 |  | Cristhian Stuani | Girona FC | 21 | 5 |
| 6 |  | Antoine Griezmann | Atlético de Madrid | 19 | 2 |
| 7 | | Maximiliano Gómez | RC Celta | 17 | 0 |
| 8 | | Gareth Bale | Real Madrid | 16 | 1 |
 | Gerard Moreno | Espanyol Barcelona | 16 | 1 | |
 | Rodrigo | Valence CF | 16 | 1 | |
| 11 |  | Carlos Bacca | Villarreal CF | 15 | 1 |
 | Willian José | Real Sociedad | 15 | 3 | |
| 13 |  | Ángel | Getafe CF | 13 | 0 |
| Simone Zaza | Valence CF | 13 | 0 | |
| 15 | | Mikel Oyarzabal | Real Sociedad | 12 | 0 |
| Santi Mina | Valence CF | 12 | 1 | |
| 17 | | Portu | Girona FC | 11 | 0 |
 | Sergio León | Betis Séville | 11 | 0 | |
| 19 |  | José Morales | Levante UD | 10 | 3 |
 | Munir | CD Alavés | 10 | 0 | |
 | Raúl García | Athletic Club | 10 | 3 | |
| 22 |  | Adrián | Deportivo La Coruña | 9 | 0 |
| Aduriz | Athletic Club | 9 | 3 | |
| Cédric Bakambu | Villarreal CF | 9 | 1 | |
| Enis Bardhi | Levante UD | 9 | 0 | |
 | Wissam Ben Yedder | Séville FC | 9 | 0 | |
 | Jonathan Calleri | UD Las Palmas | 9 | 5 | |
| Paulinho | FC Barcelone | 9 | 0 | |
| 29 |  | Charles | SD Eibar | 8 | 1 |
| Ángel Correa | Atlético de Madrid | 8 | 0 | |
| Juanmi | Real Sociedad | 8 | 0 | |
| Kike García | SD Eibar | 8 | 0 | |
| Leo Baptistão | Espanyol Barcelona | 8 | 0 | |
| Lucas Pérez | Deportivo La Coruña | 8 | 3 | |
| Philippe Coutinho | FC Barcelone | 8 | 0 | |
| Loïc Rémy | Getafe CF | 8 | 1 | |
| Antonio Sanabria | Betis Séville | 8 | 0 | |
| 38 | | Florin Andone | Deportivo La Coruña | 7 | 0 |
| Dani Parejo | Valence CF | 7 | 6 | |
| Kevin Gameiro | Atlético de Madrid | 7 | 2 | |
| Ibai | CD Alavés | 7 | 1 | |
| Illarramendi | Real Sociedad | 7 | 0 | |
| Iñaki Williams | Athletic Club | 7 | 0 | |
| Isco | Real Madrid | 7 | 0 | |
| Jorge Molina | Getafe CF | 7 | 3 | |
| Loren Morón | Betis Séville | 7 | 0 | |
| Luis Muriel | Séville FC | 7 | 0 | |
| 48 | | Emmanuel Boateng | Levante UD | 6 | 0 |
| Joan Jordán | Espanyol Barcelona | 6 | 1 | |
| Marco Asensio | Real Madrid | 6 | 0 | |
| Pablo Sarabia | Séville FC | 6 | 1 | |
| Samu Castillejo | Villarreal CF | 6 | 0 | |
| Enes Ünal | Levante UD | 6 | 0 | |
| 54 | | Karim Benzema | Real Madrid | 5 | 2 |
| Casemiro | Real Madrid | 5 | 0 | |
| Fernando Torres | Atlético de Madrid | 5 | 0 | |
 | Gabriel Pires | CD Leganés | 5 | 1 | |
| Gonçalo Guedes | Valence CF | 5 | 0 | |
| Takashi Inui | SD Eibar | 5 | 0 | |
| Juanpe | Girona FC | 5 | 0 | |
| Toni Kroos | Real Madrid | 5 | 0 | |
 | Diego Rolán | Málaga CF | 5 | 0 | |
| Nicola Sansone | Villarreal CF | 5 | 1 | |
| Pione Sisto | RC Celta | 5 | 0 | |
| 65 | | Gonzalo Castro | Málaga CF | 4 | 1 |
| Cristian Tello | Betis Séville | 4 | 0 | |
| Youssef En-Nesyri | Málaga CF | 4 | 0 | |
| Eraso | Athletic Club | 4 | 0 | |
| Guerrero | CD Leganés | 4 | 0 | |
| Ivi López | Levante UD | 4 | 1 | |
| Joaquín | Betis Séville | 4 | 0 | |
| Jonathan Viera | UD Las Palmas | 4 | 1 | |
| Koke | Atlético de Madrid | 4 | 0 | |
| Geoffrey Kondogbia | Valence CF | 4 | 0 | |
| Lucas Vázquez | Real Madrid | 4 | 0 | |
| Markel Bergara | Getafe CF | 4 | 0 | |
| Muniain | Athletic Club | 4 | 0 | |
| Nolito | Séville FC | 4 | 0 | |
| Paco Alcácer | FC Barcelone | 4 | 0 | |
| Sergio Canales | Real Sociedad | 4 | 0 | |
| Sergio Ramos | Real Madrid | 4 | 2 | |
| Franco Vázquez | Séville FC | 4 | 0 | |
| Daniel Wass | RC Celta | 4 | 0 | |
| 84 | | Adrián | Málaga CF | 3 | 1 |
| Aritz Elustondo | Real Sociedad | 3 | 0 | |
| Éver Banega | Séville FC | 3 | 3 | |
| Celso Borges | Deportivo La Coruña | 3 | 0 | |
| Borja Mayoral | Real Madrid | 3 | 0 | |
| Borja Valle | Deportivo La Coruña | 3 | 0 | |
| Yannick Carrasco | Atlético de Madrid | 3 | 0 | |
| Coke | Levante UD | 3 | 0 | |
| Ousmane Dembélé | FC Barcelone | 3 | 0 | |
| Diego Costa | Atlético de Madrid | 3 | 0 | |
| Fabián Ruiz | Betis Séville | 3 | 0 | |
| Zouhair Feddal | CD Alavés | 3 | 0 | |
| John Guidetti | CD Alavés | 3 | 0 | |
| Pablo Hernández | RC Celta | 3 | 0 | |
| Iván Ramis | SD Eibar | 3 | 0 | |
| Adnan Januzaj | Real Sociedad | 3 | 0 | |
| Clément Lenglet | Séville FC | 3 | 0 | |
| Llorente | Real Sociedad | 3 | 0 | |
| Manu García | CD Alavés | 3 | 0 | |
| Markel Susaeta | Athletic Club | 3 | 0 | |
| Nacho | Real Madrid | 3 | 0 | |
| Amath Ndiaye | Getafe CF | 3 | 0 | |
| Michael Olunga | Girona FC | 3 | 0 | |
| Fabián Orellana | SD Eibar | 3 | 0 | |
| Pablo Fornals | Málaga CF | 3 | 0 | |
| Thomas Partey | Atlético de Madrid | 3 | 0 | |
| Pedraza | CD Alavés | 3 | 0 | |
| Roger Martí | Levante UD | 3 | 1 | |
| Rubén Sobrino | CD Alavés | 3 | 0 | |
| Sergi Enrich | SD Eibar | 3 | 0 | |
| Trigueros | Villarreal CF | 3 | 1 | |
| Xabi Prieto | Real Sociedad | 3 | 1 | |
| 116 | | Aday | Girona FC | 2 | 1 |
| Nordin Amrabat | CD Leganés | 2 | 0 | |
| Arbilla | SD Eibar | 2 | 0 | |
| Claudio Beauvue | RC Celta | 2 | 0 | |
| Borja García | Girona FC | 2 | 0 | |
| Borja González | Málaga CF | 2 | 1 | |
| Ryad Boudebouz | Betis Séville | 2 | 0 | |
| Darko Brašanac | Betis Séville | 2 | 0 | |
| Bustinza | CD Leganés | 2 | 0 | |
| Cala | Getafe CF | 2 | 0 | |
| Joel Campbell | Betis Séville | 2 | 0 | |
| Federico Cartabia | Deportivo La Coruña | 2 | 0 | |
| Denis Cheryshev | Villarreal CF | 2 | 0 | |
| Dani Ceballos | Betis Séville | 2 | 0 | |
| Dani Raba | Villarreal CF | 2 | 0 | |
| David Timor | Girona FC | 2 | 0 | |
| Denis Suárez | FC Barcelone | 2 | 0 | |
| Diego Rico | CD Leganés | 2 | 0 | |
| Riza Durmisi | Betis Séville | 2 | 0 | |
| Nabil El Zhar | CD Leganés | 2 | 0 | |
| Junior Firpo | Betis Séville | 2 | 0 | |
| Ganso | Séville FC | 2 | 0 | |
| Andrés Guardado | Betis Séville | 2 | 1 | |
| Achraf Hakimi | Real Madrid | 2 | 0 | |
| Alen Halilović | UD Las Palmas | 2 | 0 | |
| Jonny | RC Celta | 2 | 0 | |
| Jordi Alba | FC Barcelone | 2 | 0 | |
| Simon Kjær | Séville FC | 2 | 0 | |
| Laguardia | CD Alavés | 2 | 0 | |
| Miguel Layún | Séville FC | 2 | 0 | |
| Marcelo | Real Madrid | 2 | 0 | |
| Mario Gaspar | Villarreal CF | 2 | 0 | |
| Medrán | CD Alavés | 2 | 0 | |
| Pablo Piatti | Espanyol Barcelona | 2 | 1 | |
| Piqué | FC Barcelone | 2 | 0 | |
| Portillo | Getafe CF | 2 | 1 | |
| Christian Santos | CD Alavés | 2 | 0 | |
| Saúl Ñíguez | Atlético de Madrid | 2 | 0 | |
| Fabian Schär | Deportivo La Coruña | 2 | 0 | |
| Sergio García | Espanyol Barcelona | 2 | 0 | |
| Alexander Szymanowski | CD Leganés | 2 | 1 | |
| Víctor Ruiz | Villarreal CF | 2 | 0 | |
| Luciano Vietto | Atlético de Madrid | 2 | 0 | |
| Vitolo | Atlético de Madrid | 2 | 0 | |
| 160 | | Aleix García | Girona FC | 1 | 0 |
| Aleix Vidal | FC Barcelone | 1 | 0 | |
| Álex Granell | Girona FC | 1 | 0 | |
| Alexis | CD Alavés | 1 | 0 | |
| Álvaro Jiménez | Getafe CF | 1 | 0 | |
| Andreas Pereira | Valence CF | 1 | 0 | |
| Mauro Arambarri | Getafe CF | 1 | 0 | |
| Paul Baysse | Málaga CF | 1 | 0 | |
| Brais Méndez | RC Celta | 1 | 0 | |
| Burgui | CD Alavés | 1 | 0 | |
| Busquets | FC Barcelone | 1 | 0 | |
| Gustavo Cabral | RC Celta | 1 | 0 | |
| Carlos Fernández | Séville FC | 1 | 0 | |
| Carlos Soler | Valence CF | 1 | 0 | |
| Chema | Levante UD | 1 | 0 | |
| Emre Çolak | Deportivo La Coruña | 1 | 0 | |
| Francis Coquelin | Valence CF | 1 | 0 | |
| Córdoba | Athletic Club | 1 | 0 | |
| Joaquín Correa | Séville FC | 1 | 0 | |
| David García | UD Las Palmas | 1 | 0 | |
| David López | Espanyol Barcelona | 1 | 0 | |
| De Marcos | Athletic Club | 1 | 0 | |
| Ermedin Demirović | CD Alavés | 1 | 0 | |
| Diego González | Málaga CF | 1 | 0 | |
| Dakonam Djené | Getafe CF | 1 | 0 | |
| Cheick Doukouré | Levante UD | 1 | 0 | |
| Erik Expósito | UD Las Palmas | 1 | 0 | |
| Gonzalo Escalante | SD Eibar | 1 | 0 | |
| Etxeita | Athletic Club | 1 | 0 | |
| Fayçal Fajr | Deportivo La Coruña | 1 | 0 | |
| Filipe Luís | Atlético de Madrid | 1 | 0 | |
| Francis Guerrero | Betis Séville | 1 | 0 | |
| Gálvez | SD Eibar | 1 | 0 | |
| Gerard Deulofeu | FC Barcelone | 1 | 0 | |
| José Giménez | Atlético de Madrid | 1 | 0 | |
| Granero | Espanyol Barcelona | 1 | 0 | |
| Gumbau | CD Leganés | 1 | 0 | |
| Brown Ideye | Málaga CF | 1 | 0 | |
| Iniesta | FC Barcelone | 1 | 0 | |
| Iñigo Martínez | Athletic Club | 1 | 0 | |
| Iván Alejo | SD Eibar | 1 | 0 | |
| Jason | Levante UD | 1 | 0 | |
| Javi García | Betis Séville | 1 | 0 | |
| Jesús Navas | Séville FC | 1 | 0 | |
| Jon Bautista | Real Sociedad | 1 | 0 | |
| José Campaña | Levante UD | 1 | 0 | |
| Joseba Zaldua | CD Leganés | 1 | 0 | |
| Michael Krohn-Dehli | Deportivo La Coruña | 1 | 0 | |
| Lombán | SD Eibar | 1 | 0 | |
| Choco Lozano | Girona FC | 1 | 0 | |
| Luisinho | Deportivo La Coruña | 1 | 0 | |
| Aïssa Mandi | Betis Séville | 1 | 0 | |
| Martín Mantovani | CD Leganés | 1 | 0 | |
| Marc Bartra | Betis Séville | 1 | 0 | |
| Mario Hermoso | Espanyol Barcelona | 1 | 0 | |
| Roger Martínez | Villarreal CF | 1 | 0 | |
| Mikel San José | Athletic Club | 1 | 0 | |
| Luka Modrić | Real Madrid | 1 | 0 | |
| Emre Mor | RC Celta | 1 | 0 | |
| Héctor Moreno | Real Sociedad | 1 | 0 | |
| Nacho Vidal | Valence CF | 1 | 0 | |
| Naranjo | CD Leganés | 1 | 0 | |
| Marc Navarro | Espanyol Barcelona | 1 | 0 | |
| Steven Nzonzi | Séville FC | 1 | 0 | |
| Mathías Olivera | Getafe CF | 1 | 0 | |
| Óscar Melendo | Espanyol Barcelona | 1 | 0 | |
| Giampaolo Pazzini | Levante UD | 1 | 0 | |
| Pedro Alcalá | Girona FC | 1 | 0 | |
| Pina | CD Alavés | 1 | 0 | |
| Guido Pizarro | Séville FC | 1 | 0 | |
| Ivan Rakitić | FC Barcelone | 1 | 0 | |
| Raúl Albentosa | Deportivo La Coruña | 1 | 0 | |
| Recio | Málaga CF | 1 | 1 | |
| Rodri | Villarreal CF | 1 | 0 | |
| Rodrigo Ely | CD Alavés | 1 | 0 | |
| Kévin Rodrigues | Real Sociedad | 1 | 0 | |
| Roberto Rosales | Málaga CF | 1 | 0 | |
| Rubén Castro | Betis Séville | 1 | 1 | |
| Rubén Peña | SD Eibar | 1 | 0 | |
| Rubén Rochina | Levante UD | 1 | 0 | |
| Sergi Darder | Espanyol Barcelona | 1 | 0 | |
| Sergi Gómez | RC Celta | 1 | 0 | |
| Sergi Roberto | FC Barcelone | 1 | 0 | |
| Sergio Postigo | Levante UD | 1 | 0 | |
| Gaku Shibasaki | Getafe CF | 1 | 0 | |
| Sidnei | Deportivo La Coruña | 1 | 0 | |
| Dimitrios Siovas | CD Leganés | 1 | 0 | |
| Damián Suárez | Getafe CF | 1 | 0 | |
| Tana | UD Las Palmas | 1 | 0 | |
| Samuel Umtiti | FC Barcelone | 1 | 0 | |
| Unai Núñez | Athletic Club | 1 | 0 | |
| Carlos Vela | Real Sociedad | 1 | 0 | |
| Vesga | Athletic Club | 1 | 0 | |
| Víctor Camarasa | Betis Séville | 1 | 0 | |
| Zubeldia | Real Sociedad | 1 | 0 |
