| # | Nom | Équipe | Buts | Pén | |
|---|---|---|---|---|---|
| 1 |  | Lionel Messi | FC Barcelone | 36 | 4 |
| 2 |  | Karim Benzema | Real Madrid | 21 | 3 |
| Luis Suárez | FC Barcelone | 21 | 4 | |
| 4 |  | Iago Aspas | RC Celta | 20 | 5 |
| 5 |  | Cristhian Stuani | Girona FC | 19 | 5 |
| 6 |  | Wissam Ben Yedder | Séville FC | 18 | 2 |
| 7 | | Borja Iglesias | RC Celta | 17 | 3 |
| 8 |  | Antoine Griezmann | Atlético de Madrid | 15 | 3 |
| 9 |  | Charles | SD Eibar | 14 | 6 |
 | Jaime Mata | Getafe CF | 14 | 4 | |
| Jorge Molina | Getafe CF | 14 | 2 | |
 | Raúl de Tomás | Rayo Vallecano | 14 | 0 | |
| 13 | | Maximiliano Gómez | RC Celta | 13 | 1 |
 | Iñaki Williams | Athletic Club | 13 | 0 | |
 | Mikel Oyarzabal | Real Sociedad | 13 | 3 | |
 | Roger Martí | Levante UD | 13 | 2 | |
| 17 | | José Morales | Levante UD | 12 | 3 |
| Pablo Sarabia | Séville FC | 12 | 1 | |
| 19 | | Willian José | Real Sociedad | 11 | 5 |
| 20 |  | Chimy Ávila | SD Huesca | 10 | 1 |
 | Karl Toko Ekambi | Villarreal CF | 10 | 0 | |
| 22 | | André Silva | Séville FC | 9 | 0 |
 | Jonathan Calleri | CD Alavés | 9 | 2 | |
 | Dani Parejo | Valence CF | 9 | 5 | |
 | Youssef En-Nesyri | CD Leganés | 9 | 0 | |
 | Giovani Lo Celso | Betis Séville | 9 | 2 | |
| Portu | Girona FC | 9 | 1 | |
| Raúl García | Athletic Club | 9 | 2 | |
| 29 | | Ángel | Getafe CF | 8 | 0 |
| Gareth Bale | Real Madrid | 8 | 1 | |
| Ousmane Dembélé | FC Barcelone | 8 | 0 | |
| Gerard Moreno | Villarreal CF | 8 | 0 | |
| Rodrigo | Valence CF | 8 | 0 | |
| 34 | | Muniain | Athletic Club | 7 | 1 |
| Santi Mina | Valence CF | 7 | 0 | |
| Sergi Enrich | SD Eibar | 7 | 0 | |
| Sergio Canales | Betis Séville | 7 | 2 | |
| 38 | | Álvaro Morata | Atlético de Madrid | 6 | 0 |
| Carlos Bacca | Villarreal CF | 6 | 1 | |
| Brais Méndez | RC Celta | 6 | 1 | |
| Guido Carrillo | CD Leganés | 6 | 1 | |
| Kevin Gameiro | Atlético de Madrid | 6 | 0 | |
| Joaquín | Betis Séville | 6 | 0 | |
| Loren Morón | Betis Séville | 6 | 0 | |
| Munir | FC Barcelone | 6 | 0 | |
| Sergio Ramos | Real Madrid | 6 | 5 | |
 | Enes Ünal | Real Valladolid | 6 | 3 | |
| 48 | | Adrián Embarba | Rayo Vallecano | 5 | 3 |
| Borja González | CD Alavés | 5 | 0 | |
| Samuel Chukwueze | Villarreal CF | 5 | 0 | |
| Enric Gallego | SD Huesca | 5 | 0 | |
| Gonçalo Guedes | Valence CF | 5 | 0 | |
| Jony | CD Alavés | 5 | 0 | |
| Juanmi | Real Sociedad | 5 | 0 | |
| Philippe Coutinho | FC Barcelone | 5 | 0 | |
| 56 | | Álex Gallar | SD Huesca | 4 | 1 |
| Álvaro García | Rayo Vallecano | 4 | 0 | |
| Martin Braithwaite | CD Leganés | 4 | 0 | |
| Coke | Levante UD | 4 | 0 | |
| Cristian Tello | Betis Séville | 4 | 0 | |
| Nabil El Zhar | CD Leganés | 4 | 1 | |
| Gonzalo Escalante | SD Eibar | 4 | 0 | |
| Etxeita | Athletic Club | 4 | 0 | |
| Cucho Hernández | SD Huesca | 4 | 2 | |
| Joan Jordán | SD Eibar | 4 | 0 | |
| José Campaña | Levante UD | 4 | 0 | |
| Óscar | CD Leganés | 4 | 0 | |
| Piqué | FC Barcelone | 4 | 0 | |
| Rubén Rochina | Levante UD | 4 | 0 | |
| Santi Cazorla | Villarreal CF | 4 | 2 | |
| Saúl Ñíguez | Atlético de Madrid | 4 | 0 | |
 | Sergi Darder | Espanyol Barcelona | 4 | 0 | |
| 73 | | Alcaraz | Girona FC | 3 | 0 |
| Néstor Araujo | RC Celta | 3 | 0 | |
| Éver Banega | Séville FC | 3 | 2 | |
| Enis Bardhi | Levante UD | 3 | 0 | |
| Borja Mayoral | Levante UD | 3 | 0 | |
| Sofiane Boufal | RC Celta | 3 | 0 | |
| Casemiro | Real Madrid | 3 | 0 | |
| Ángel Correa | Atlético de Madrid | 3 | 0 | |
| Dani Ceballos | Real Madrid | 3 | 0 | |
| Junior Firpo | Betis Séville | 3 | 0 | |
| Dimitri Foulquier | Getafe CF | 3 | 0 | |
| Diego Godín | Atlético de Madrid | 3 | 0 | |
| Granero | Espanyol Barcelona | 3 | 0 | |
| Ibai | Athletic Club | 3 | 0 | |
| Iborra | Villarreal CF | 3 | 0 | |
| Isco | Real Madrid | 3 | 0 | |
| Jorge Pulido | SD Huesca | 3 | 0 | |
| José Pozo | Rayo Vallecano | 3 | 0 | |
| Kike García | SD Eibar | 3 | 0 | |
| Koke | Atlético de Madrid | 3 | 0 | |
| Thomas Lemar | Atlético de Madrid | 3 | 0 | |
| Marc Cardona | SD Eibar | 3 | 0 | |
| Mariano | Real Madrid | 3 | 0 | |
| Mario Hermoso | Espanyol Barcelona | 3 | 0 | |
| Medrán | Rayo Vallecano | 3 | 0 | |
| Mikel Merino | Real Sociedad | 3 | 0 | |
| Luka Modrić | Real Madrid | 3 | 0 | |
| Fabián Orellana | SD Eibar | 3 | 1 | |
| Óscar Plano | Real Valladolid | 3 | 0 | |
| Thomas Partey | Atlético de Madrid | 3 | 0 | |
| Pedraza | Villarreal CF | 3 | 0 | |
| Ivan Rakitić | FC Barcelone | 3 | 0 | |
| Rodri | Atlético de Madrid | 3 | 0 | |
| Roberto Rosales | Espanyol Barcelona | 3 | 0 | |
| Rubén Sobrino | CD Alavés | 3 | 0 | |
| Sergi Guardiola | Getafe CF | 3 | 0 | |
| Jonathan Silva | CD Leganés | 3 | 0 | |
| Franco Vázquez | Séville FC | 3 | 0 | |
| Arturo Vidal | FC Barcelone | 3 | 0 | |
| Lei Wu | Espanyol Barcelona | 3 | 0 | |
| 113 | | Aduriz | Athletic Club | 2 | 2 |
| Aleix García | Girona FC | 2 | 0 | |
| Antoñito | Real Valladolid | 2 | 0 | |
| Erick Cabaco | Levante UD | 2 | 0 | |
| Leandro Cabrera | Getafe CF | 2 | 0 | |
| Carles Aleñá | FC Barcelone | 2 | 0 | |
| Carlos Soler | Valence CF | 2 | 0 | |
| Chema | Levante UD | 2 | 0 | |
| Denis Cheryshev | Valence CF | 2 | 0 | |
| Christian Rivera | SD Eibar | 2 | 0 | |
| Pablo de Blasis | SD Eibar | 2 | 0 | |
| Mouctar Diakhaby | Valence CF | 2 | 0 | |
| Diego Costa | Atlético de Madrid | 2 | 0 | |
| Seydou Doumbia | Girona FC | 2 | 0 | |
| Ferran Torres | Valence CF | 2 | 0 | |
| Filipe Luís | Atlético de Madrid | 2 | 0 | |
| Ramiro Funes Mori | Villarreal CF | 2 | 0 | |
| Ezequiel Garay | Valence CF | 2 | 0 | |
| Gonzalo Melero | SD Huesca | 2 | 1 | |
| John Guidetti | CD Alavés | 2 | 0 | |
| Takashi Inui | CD Alavés | 2 | 0 | |
| Jason | Levante UD | 2 | 0 | |
| Jesé | Betis Séville | 2 | 0 | |
| Jordi Alba | FC Barcelone | 2 | 0 | |
| Juanpi | SD Huesca | 2 | 1 | |
| Nikola Kalinić | Atlético de Madrid | 2 | 0 | |
| Keko | Real Valladolid | 2 | 0 | |
| Leo Baptistão | Espanyol Barcelona | 2 | 1 | |
| Martín Mantovani | SD Huesca | 2 | 0 | |
| Marcelo | Real Madrid | 2 | 0 | |
| Mario Suárez | Rayo Vallecano | 2 | 0 | |
| Guillermo Maripán | CD Alavés | 2 | 0 | |
| Gabriel Mercado | Séville FC | 2 | 0 | |
| Moi Gómez | SD Huesca | 2 | 0 | |
| Nolaskoain | Athletic Club | 2 | 0 | |
| Pablo Fornals | Villarreal CF | 2 | 0 | |
| Pina | CD Alavés | 2 | 0 | |
| Quincy Promes | Séville FC | 2 | 0 | |
| Roque Mesa | Séville FC | 2 | 0 | |
| Rúben Vezo | Levante UD | 2 | 0 | |
| Antonio Sanabria | Betis Séville | 2 | 1 | |
| Sergio García | Espanyol Barcelona | 2 | 0 | |
| Pione Sisto | RC Celta | 2 | 0 | |
| Leonardo Suárez | Real Valladolid | 2 | 0 | |
| Toni Villa | Real Valladolid | 2 | 0 | |
| Raphaël Varane | Real Madrid | 2 | 0 | |
| Daniele Verde | Real Valladolid | 2 | 1 | |
| Vinícius Junior | Real Madrid | 2 | 0 | |
| Ximo Navarro | CD Alavés | 2 | 0 | |
| Okay Yokuşlu | RC Celta | 2 | 0 | |
| Yuri | Athletic Club | 2 | 0 | |
| David Zurutuza | Real Sociedad | 2 | 0 | |
| 165 | | Adrià Pedrosa | Espanyol Barcelona | 1 | 0 |
| Luis Advíncula | Rayo Vallecano | 1 | 0 | |
| Álex Moreno | Rayo Vallecano | 1 | 0 | |
| Álvaro González | Villarreal CF | 1 | 0 | |
| Ander Barrenetxea | Real Sociedad | 1 | 0 | |
| Antunes | Getafe CF | 1 | 0 | |
| Mauro Arambarri | Getafe CF | 1 | 0 | |
| Arbilla | SD Eibar | 1 | 0 | |
| Santiago Arias | Atlético de Madrid | 1 | 0 | |
| Aritz Elustondo | Real Sociedad | 1 | 0 | |
| Abdoulaye Ba | Rayo Vallecano | 1 | 0 | |
| Michy Batshuayi | Valence CF | 1 | 0 | |
| Bebé | Rayo Vallecano | 1 | 0 | |
| Beñat | Athletic Club | 1 | 0 | |
| Emmanuel Boateng | Levante UD | 1 | 0 | |
| Borja Garcés | Atlético de Madrid | 1 | 0 | |
| Borja García | Girona FC | 1 | 0 | |
| Ryad Boudebouz | RC Celta | 1 | 0 | |
| Brahim Díaz | Real Madrid | 1 | 0 | |
| Bryan Gil | Séville FC | 1 | 0 | |
| Burgui | CD Alavés | 1 | 0 | |
| Cote | SD Eibar | 1 | 0 | |
| Cucurella | FC Barcelone | 1 | 0 | |
| Dani Carvajal | Real Madrid | 1 | 0 | |
| Daniel Carriço | Séville FC | 1 | 0 | |
| David Ferreiro | SD Huesca | 1 | 0 | |
| De Marcos | Athletic Club | 1 | 0 | |
| Pape Diop | SD Eibar | 1 | 0 | |
| Bernardo Espinosa | Girona FC | 1 | 0 | |
| Zouhair Feddal | Betis Séville | 1 | 0 | |
| Fernando Calero | Real Valladolid | 1 | 0 | |
| Facundo Ferreyra | Espanyol Barcelona | 1 | 0 | |
| Fran Beltrán | RC Celta | 1 | 0 | |
| Gálvez | Rayo Vallecano | 1 | 0 | |
| Gayà | Valence CF | 1 | 0 | |
| Gumbau | CD Leganés | 1 | 1 | |
| Lucas Hernández | Atlético de Madrid | 1 | 0 | |
| Theo Hernández | Real Madrid | 1 | 0 | |
| Hugo Mallo | RC Celta | 1 | 0 | |
| Illarramendi | Real Sociedad | 1 | 0 | |
| Giannelli Imbula | Rayo Vallecano | 1 | 0 | |
| Adnan Januzaj | Real Sociedad | 1 | 0 | |
| Jaume Costa | Villarreal CF | 1 | 0 | |
| Jesús Navas | Séville FC | 1 | 0 | |
| Jesús Vallejo | Real Madrid | 1 | 0 | |
| Joaquín | Real Valladolid | 1 | 0 | |
| Jon Bautista | Real Sociedad | 1 | 0 | |
| Jorge Miramón | SD Huesca | 1 | 0 | |
| Joseba Zaldua | Real Sociedad | 1 | 0 | |
| Juanfran | CD Leganés | 1 | 0 | |
| Gaël Kakuta | Rayo Vallecano | 1 | 1 | |
| Kenan Kodro | Athletic Club | 1 | 0 | |
| Geoffrey Kondogbia | Valence CF | 1 | 0 | |
| Laguardia | CD Alavés | 1 | 0 | |
| Clément Lenglet | FC Barcelone | 1 | 0 | |
| Samuele Longo | SD Huesca | 1 | 0 | |
| Luca Sangalli | Real Sociedad | 1 | 0 | |
| Lucas Vázquez | Real Madrid | 1 | 0 | |
| Nemanja Maksimović | Getafe CF | 1 | 0 | |
| Malcom | FC Barcelone | 1 | 0 | |
| Aïssa Mandi | Betis Séville | 1 | 0 | |
| Manu García | CD Alavés | 1 | 0 | |
| Marc Bartra | Betis Séville | 1 | 0 | |
| Marc Roca | Espanyol Barcelona | 1 | 0 | |
| Marco Asensio | Real Madrid | 1 | 0 | |
| Mario Gaspar | Villarreal CF | 1 | 0 | |
| Markel Susaeta | Athletic Club | 1 | 0 | |
| Míchel | Real Valladolid | 1 | 0 | |
| Héctor Moreno | Real Sociedad | 1 | 0 | |
| Luis Muriel | Séville FC | 1 | 0 | |
| Nacho | Real Valladolid | 1 | 0 | |
| Naldo | Espanyol Barcelona | 1 | 0 | |
| Amath Ndiaye | Getafe CF | 1 | 0 | |
| Nélson Semedo | FC Barcelone | 1 | 0 | |
| Allan Nyom | CD Leganés | 1 | 0 | |
| Pedro Alcalá | Girona FC | 1 | 0 | |
| Pedro León | SD Eibar | 1 | 0 | |
| Pere Pons | Girona FC | 1 | 0 | |
| Hernán Pérez | Espanyol Barcelona | 1 | 0 | |
| Pablo Piatti | Espanyol Barcelona | 1 | 0 | |
| Cristiano Piccini | Valence CF | 1 | 0 | |
| Portillo | Getafe CF | 1 | 0 | |
| Ramalho | Girona FC | 1 | 0 | |
| Róber | Levante UD | 1 | 0 | |
| Rubén Pardo | Real Sociedad | 1 | 0 | |
| Rubén Peña | SD Eibar | 1 | 0 | |
| Samu Sáiz | Getafe CF | 1 | 0 | |
| Nicola Sansone | Villarreal CF | 1 | 0 | |
| Santi Comesaña | Rayo Vallecano | 1 | 0 | |
| Michael Santos | CD Leganés | 1 | 0 | |
| Sergio Camello | Atlético de Madrid | 1 | 0 | |
| Sergio Postigo | Levante UD | 1 | 0 | |
| Sidnei | Betis Séville | 1 | 0 | |
| Moses Simon | Levante UD | 1 | 0 | |
| Dimitrios Siovas | CD Leganés | 1 | 0 | |
| Toño García | Levante UD | 1 | 0 | |
| Óscar Trejo | Rayo Vallecano | 1 | 1 | |
| Anuar Tuhami | Real Valladolid | 1 | 0 | |
| Vesga | CD Leganés | 1 | 0 | |
| Mubarak Wakaso | CD Alavés | 1 | 0 | |
| Waldo Rubio | Real Valladolid | 1 | 0 | |
| Daniel Wass | RC Celta | 1 | 0 |
