| # | Nom | Équipe | Buts | Pén | |
|---|---|---|---|---|---|
| 1 |  | Lionel Messi | FC Barcelone | 30 | 3 |
| 2 |  | Karim Benzema | Real Madrid | 23 | 1 |
 | Gerard Moreno | Villarreal CF | 23 | 10 | |
| 4 |  | Luis Suárez | Atlético de Madrid | 21 | 3 |
| 5 |  | Youssef En-Nesyri | Séville FC | 18 | 0 |
| 6 |  | Alexander Isak | Real Sociedad | 17 | 0 |
| 7 |  | Iago Aspas | RC Celta | 14 | 5 |
 | José Morales | Levante UD | 14 | 0 | |
| 9 | | Antoine Griezmann | FC Barcelone | 13 | 1 |
 | Rafa Mir | SD Huesca | 13 | 2 | |
| 11 |  | Kike García | SD Eibar | 12 | 0 |
| Marcos Llorente | Atlético de Madrid | 12 | 0 | |
| Roger Martí | Levante UD | 12 | 2 | |
| Santi Mina | RC Celta | 12 | 1 | |
| 15 |  | Borja Iglesias | Betis Séville | 11 | 5 |
 | Ante Budimir | CA Osasuna | 11 | 0 | |
 | Carlos Soler | Valence CF | 11 | 7 | |
 | Joselu | CD Alavés | 11 | 2 | |
| Mikel Oyarzabal | Real Sociedad | 11 | 6 | |
| 20 | | Brais Méndez | RC Celta | 9 | 1 |
| Ángel Correa | Atlético de Madrid | 9 | 0 | |
 | Soldado | Granada CF | 9 | 2 | |
| 23 |  | Álex Berenguer | Athletic Bilbao | 8 | 0 |
 | Álvaro Negredo | Cádiz CF | 8 | 0 | |
 | Jorge Molina | Getafe CF | 8 | 0 | |
| Portu | Real Sociedad | 8 | 0 | |
| Sergio Canales | Betis Séville | 8 | 2 | |
| 28 |  | Lucas Boyé | Elche CF | 7 | 0 |
| Maximiliano Gómez | Valence CF | 7 | 0 | |
| Gonzalo Melero | Levante UD | 7 | 0 | |
| João Félix | Atlético de Madrid | 7 | 1 | |
| Nolito | RC Celta | 7 | 0 | |
| Roberto Torres | CA Osasuna | 7 | 4 | |
| 34 | | Yannick Carrasco | Atlético de Madrid | 6 | 0 |
| Casemiro | Real Madrid | 6 | 0 | |
| Ousmane Dembélé | FC Barcelone | 6 | 0 | |
| Fidel | Elche CF | 6 | 2 | |
| Iñaki Williams | Athletic Bilbao | 6 | 1 | |
 | Fabián Orellana | Real Valladolid | 6 | 4 | |
| Paco Alcácer | Villarreal CF | 6 | 1 | |
| Shon Weissman | Real Valladolid | 6 | 0 | |
| 42 | | Ángel | Getafe CF | 5 | 1 |
| Carlos Bacca | Villarreal CF | 5 | 0 | |
| Jonathan Calleri | CA Osasuna | 5 | 0 | |
| Cristian Tello | Betis Séville | 5 | 0 | |
| Édgar Méndez | CD Alavés | 5 | 0 | |
| Nabil Fekir | Betis Séville | 5 | 1 | |
| Gonçalo Guedes | Valence CF | 5 | 0 | |
| Jaime Mata | Getafe CF | 5 | 1 | |
| Manu Vallejo | Valence CF | 5 | 0 | |
| Marco Asensio | Real Madrid | 5 | 0 | |
| Luka Modrić | Real Madrid | 5 | 0 | |
| Muniain | Athletic Bilbao | 5 | 0 | |
| Lucas Ocampos | Séville FC | 5 | 4 | |
| Óscar Plano | Real Valladolid | 5 | 0 | |
| Raúl García | Athletic Bilbao | 5 | 2 | |
| Sandro | Real Valladolid | 5 | 0 | |
| Luis Suárez | Granada CF | 5 | 0 | |
| 59 | | Álex | Cádiz CF | 4 | 2 |
| Ansu Fati | FC Barcelone | 4 | 0 | |
| Bryan Gil | SD Eibar | 4 | 0 | |
| Samuel Chukwueze | Villarreal CF | 4 | 0 | |
| Luuk de Jong | Séville FC | 4 | 0 | |
| Gabriel Paulista | Valence CF | 4 | 0 | |
| Kevin Gameiro | Valence CF | 4 | 0 | |
| Adnan Januzaj | Real Sociedad | 4 | 3 | |
| Jorge De Frutos | Levante UD | 4 | 0 | |
| Josan | Elche CF | 4 | 0 | |
| Kenedy | Getafe CF | 4 | 0 | |
| Lucas Pérez | CD Alavés | 4 | 3 | |
| Luis Rioja | CD Alavés | 4 | 0 | |
| Darwin Machís | Granada CF | 4 | 0 | |
| Marcos André | Real Valladolid | 4 | 0 | |
| Moi Gómez | Villarreal CF | 4 | 1 | |
| Munir | Séville FC | 4 | 0 | |
| Pere Milla | Elche CF | 4 | 0 | |
| Ivan Rakitić | FC Barcelone | 4 | 2 | |
| Enes Ünal | Getafe CF | 4 | 1 | |
| Villalibre | Athletic Bilbao | 4 | 0 | |
| Daniel Wass | Valence CF | 4 | 1 | |
| 81 | | Ander Barrenetxea | Real Sociedad | 3 | 0 |
| Mauro Arambarri | Getafe CF | 3 | 0 | |
| Esteban Burgos | SD Eibar | 3 | 2 | |
| Cala | Cádiz CF | 3 | 0 | |
| Guido Carrillo | Elche CF | 3 | 0 | |
| Cucurella | Getafe CF | 3 | 0 | |
| Dani Parejo | Valence CF | 3 | 0 | |
| Frenkie de Jong | FC Barcelone | 3 | 0 | |
| Fer Niño | Villarreal CF | 3 | 0 | |
| Fernando | Séville FC | 3 | 0 | |
| Fran Beltrán | RC Celta | 3 | 0 | |
| Germán | Granada CF | 3 | 0 | |
| Papu Gómez | Séville FC | 3 | 0 | |
| Eden Hazard | Real Madrid | 3 | 0 | |
| Yangel Herrera | Granada CF | 3 | 0 | |
| Hugo Mallo | RC Celta | 3 | 0 | |
| Jordi Alba | FC Barcelone | 3 | 0 | |
| Toni Kroos | Real Madrid | 3 | 0 | |
| Choco Lozano | Cádiz CF | 3 | 0 | |
| Aïssa Mandi | Betis Séville | 3 | 0 | |
| Pedri | FC Barcelone | 3 | 0 | |
| Puertas | Granada CF | 3 | 0 | |
| Raúl Guti | Elche CF | 3 | 0 | |
| Roberto López | Real Sociedad | 3 | 0 | |
| Rubén García | CA Osasuna | 3 | 1 | |
| Antonio Sanabria | Betis Séville | 3 | 0 | |
| Sergi Enrich | SD Eibar | 3 | 0 | |
| Suso | Séville FC | 3 | 0 | |
| Trincão | FC Barcelone | 3 | 0 | |
| Unai López | Athletic Bilbao | 3 | 0 | |
| Federico Valverde | Real Madrid | 3 | 0 | |
| Vinícius Junior | Real Madrid | 3 | 0 | |
| Willian José | Real Sociedad | 3 | 0 | |
| Yéremy | Villarreal CF | 3 | 0 | |
| 115 | | Aitor Ruibal | Betis Séville | 2 | 0 |
| Alberto Perea | Cádiz CF | 2 | 0 | |
| Álvaro Giménez | Cádiz CF | 2 | 0 | |
| Álvaro Odriozola | Real Madrid | 2 | 0 | |
| Ronald Araújo | FC Barcelone | 2 | 0 | |
| Martin Braithwaite | FC Barcelone | 2 | 0 | |
| Darko Brašanac | CA Osasuna | 2 | 0 | |
| Capa | Athletic Bilbao | 2 | 0 | |
| Carles Aleñá | Getafe CF | 2 | 0 | |
| Dani Calvo | Elche CF | 2 | 0 | |
| Dani Gómez | Levante UD | 2 | 0 | |
| David Ferreiro | SD Huesca | 2 | 0 | |
| David Silva | Real Sociedad | 2 | 0 | |
| Sergiño Dest | FC Barcelone | 2 | 0 | |
| Diego Costa | Atlético de Madrid | 2 | 1 | |
| Domingos Quina | Granada CF | 2 | 0 | |
| Cucho Hernández | Getafe CF | 2 | 0 | |
| Javi Ontiveros | SD Huesca | 2 | 1 | |
| Joaquín | Betis Séville | 2 | 0 | |
| Juanmi | Betis Séville | 2 | 0 | |
| Kike Barja | CA Osasuna | 2 | 0 | |
| Jules Koundé | Séville FC | 2 | 0 | |
| Lucas Vázquez | Real Madrid | 2 | 0 | |
| Marcos López | Cádiz CF | 2 | 0 | |
| Míchel | Real Valladolid | 2 | 0 | |
| Mikel Merino | Real Sociedad | 2 | 0 | |
| Moncayola | CA Osasuna | 2 | 0 | |
| Morcillo | Athletic Bilbao | 2 | 0 | |
| Jeison Murillo | RC Celta | 2 | 0 | |
| Oihan Sancet | Athletic Bilbao | 2 | 0 | |
| Óscar Mingueza | FC Barcelone | 2 | 0 | |
| Pau Torres | Villarreal CF | 2 | 0 | |
| Pere Pons | CD Alavés | 2 | 0 | |
| Philippe Coutinho | FC Barcelone | 2 | 0 | |
| Salvi | Cádiz CF | 2 | 0 | |
| Saúl | Atlético de Madrid | 2 | 0 | |
| Sergio León | Levante UD | 2 | 0 | |
| Sergio Ramos | Real Madrid | 2 | 2 | |
| Dimitrios Siovas | SD Huesca | 2 | 0 | |
| Augusto Solari | RC Celta | 2 | 0 | |
| Tete Morente | Elche CF | 2 | 0 | |
| Toni Villa | Real Valladolid | 2 | 0 | |
| Raphaël Varane | Real Madrid | 2 | 0 | |
| Víctor Ruiz | Betis Séville | 2 | 0 | |
| William Carvalho | Betis Séville | 2 | 0 | |
| 160 | | Marcos Acuña | Séville FC | 1 | 0 |
| Adrián | CA Osasuna | 1 | 0 | |
| Alberto Soro | Granada CF | 1 | 0 | |
| Alcaraz | Real Valladolid | 1 | 0 | |
| Álex Blanco | Valence CF | 1 | 0 | |
| Aritz Elustondo | Real Sociedad | 1 | 0 | |
| Baeza | RC Celta | 1 | 0 | |
| Enis Bardhi | Levante UD | 1 | 0 | |
| Rodrigo Battaglia | CD Alavés | 1 | 0 | |
| Bono | Séville FC | 1 | 0 | |
| Borja García | SD Huesca | 1 | 0 | |
| Borja Sainz | CD Alavés | 1 | 0 | |
| Bruno | Real Valladolid | 1 | 0 | |
| Étienne Capoue | Villarreal CF | 1 | 0 | |
| Carlos Akapo | Cádiz CF | 1 | 0 | |
| Carlos Fernández | Real Sociedad | 1 | 0 | |
| Dani Escriche | Elche CF | 1 | 0 | |
| David García | CA Osasuna | 1 | 0 | |
| De Marcos | Athletic Bilbao | 1 | 0 | |
| Deyverson | CD Alavés | 1 | 0 | |
| Mouctar Diakhaby | Valence CF | 1 | 0 | |
| Diego Carlos | Séville FC | 1 | 0 | |
| Diego González | Elche CF | 1 | 0 | |
| Pape Diop | SD Eibar | 1 | 0 | |
| Marko Dmitrović | SD Eibar | 1 | 1 | |
| Domingos Duarte | Granada CF | 1 | 0 | |
| Duarte | CD Alavés | 1 | 0 | |
| Óscar Duarte | Levante UD | 1 | 0 | |
| Eder Militão | Real Madrid | 1 | 0 | |
| Emerson Royal | Betis Séville | 1 | 0 | |
| Sergio Escudero | Séville FC | 1 | 0 | |
| Facundo Ferreyra | RC Celta | 1 | 0 | |
| Junior Firpo | FC Barcelone | 1 | 0 | |
| Gayà | Valence CF | 1 | 0 | |
| Andrés Guardado | Betis Séville | 1 | 0 | |
| Guevara | Real Sociedad | 1 | 0 | |
| John Guidetti | CD Alavés | 1 | 0 | |
| Hugo Guillamón | Valence CF | 1 | 0 | |
| Ilaix Moriba | FC Barcelone | 1 | 0 | |
| Iñigo Martínez | Athletic Bilbao | 1 | 0 | |
| Takashi Inui | SD Eibar | 1 | 0 | |
| Iván Alejo | Cádiz CF | 1 | 0 | |
| Jairo | Cádiz CF | 1 | 0 | |
| Javi Galán | SD Huesca | 1 | 0 | |
| Javi Martínez | CA Osasuna | 1 | 0 | |
| Joan Jordán | Séville FC | 1 | 0 | |
| Joaquín | Real Valladolid | 1 | 0 | |
| Jorge Pulido | SD Huesca | 1 | 0 | |
| José Campaña | Levante UD | 1 | 1 | |
| José Mari | Cádiz CF | 1 | 1 | |
| Jota | Real Valladolid | 1 | 0 | |
| Juan Miranda | Betis Séville | 1 | 0 | |
| Kenan Kodro | Athletic Bilbao | 1 | 1 | |
| Koke | Atlético de Madrid | 1 | 0 | |
| Takefusa Kubo | Getafe CF | 1 | 0 | |
| Florian Lejeune | CD Alavés | 1 | 0 | |
| Thomas Lemar | Atlético de Madrid | 1 | 0 | |
| Clément Lenglet | FC Barcelone | 1 | 0 | |
| Luis Milla | Granada CF | 1 | 0 | |
| Nemanja Maksimović | Getafe CF | 1 | 0 | |
| Mickaël Malsa | Levante UD | 1 | 0 | |
| Mariano | Real Madrid | 1 | 0 | |
| Mario Hermoso | Atlético de Madrid | 1 | 0 | |
| Ferland Mendy | Real Madrid | 1 | 0 | |
| Mikel Rico | SD Huesca | 1 | 0 | |
| Montoro | Granada CF | 1 | 1 | |
| Loren Morón | Betis Séville | 1 | 0 | |
| Yunus Musah | Valence CF | 1 | 0 | |
| Yoshinori Mutō | SD Eibar | 1 | 0 | |
| Nacho | Real Madrid | 1 | 0 | |
| Nacho Monreal | Real Sociedad | 1 | 0 | |
| Shinji Okazaki | SD Huesca | 1 | 0 | |
| Lucas Olaza | RC Celta | 1 | 0 | |
| Pablo Maffeo | SD Huesca | 1 | 0 | |
| Pedraza | Villarreal CF | 1 | 0 | |
| Pedro León | SD Eibar | 1 | 0 | |
| Pina | CD Alavés | 1 | 0 | |
| Pombo | Cádiz CF | 1 | 0 | |
| Quini | Granada CF | 1 | 0 | |
| Uroš Račić | Valence CF | 1 | 0 | |
| Raúl Carnero | Real Valladolid | 1 | 0 | |
| Recio | SD Eibar | 1 | 1 | |
| Renan Lodi | Atlético de Madrid | 1 | 0 | |
| Emiliano Rigoni | Elche CF | 1 | 0 | |
| Riqui Puig | FC Barcelone | 1 | 0 | |
| Rodrigo Ely | CD Alavés | 1 | 0 | |
| Kévin Rodrigues | Real Sociedad | 1 | 0 | |
| Guido Rodríguez | Betis Séville | 1 | 0 | |
| Rodrygo | Real Madrid | 1 | 0 | |
| Facundo Roncaglia | CA Osasuna | 1 | 0 | |
| Roque Mesa | Real Valladolid | 1 | 1 | |
| Rubén Peña | Villarreal CF | 1 | 0 | |
| Rubén Sobrino | Cádiz CF | 1 | 0 | |
| Rúben Vezo | Levante UD | 1 | 0 | |
| Iván Šaponjić | Atlético de Madrid | 1 | 1 | |
| Stefan Savić | Atlético de Madrid | 1 | 0 | |
| Seoane | SD Huesca | 1 | 0 | |
| Sergi Guardiola | Real Valladolid | 1 | 1 | |
| Sergi Roberto | FC Barcelone | 1 | 0 | |
| Sergio Carreira | RC Celta | 1 | 0 | |
| Damián Suárez | Getafe CF | 1 | 0 | |
| Thierry Correia | Valence CF | 1 | 0 | |
| Toni Lato | CA Osasuna | 1 | 0 | |
| Lucas Torreira | Atlético de Madrid | 1 | 0 | |
| Trigueros | Villarreal CF | 1 | 0 | |
| Unai Núñez | Athletic Bilbao | 1 | 0 | |
| Franco Vázquez | Séville FC | 1 | 0 | |
| Waldo Rubio | Real Valladolid | 1 | 1 | |
| Ximo Navarro | CD Alavés | 1 | 0 | |
| Yeray | Athletic Bilbao | 1 | 0 | |
| Yuri | Athletic Bilbao | 1 | 0 | |
| Zubeldía | Real Sociedad | 1 | 0 |
