| # | Nom | Équipe | Buts | Pén | |
|---|---|---|---|---|---|
| 1 |  | Lionel Messi | FC Barcelone | 37 | 6 |
| 2 | | Luis Suárez | FC Barcelone | 29 | 0 |
| 3 |  | Cristiano Ronaldo | Real Madrid | 25 | 6 |
| 4 |  | Iago Aspas | RC Celta | 19 | 6 |
| 5 |  | Aduriz | Athletic Bilbao | 16 | 5 |
 | Antoine Griezmann | Atlético de Madrid | 16 | 0 | |
| 7 | | Álvaro Morata | Real Madrid | 15 | 0 |
| 8 |  | Sandro | Málaga CF | 14 | 0 |
| 9 |  | Gerard Moreno | Espanyol Barcelona | 13 | 0 |
| Neymar | FC Barcelone | 13 | 1 | |
 | Rubén Castro | Betis Séville | 13 | 2 | |
| 12 |  | Florin Andone | Deportivo La Coruña | 12 | 0 |
| Kevin Gameiro | Atlético de Madrid | 12 | 1 | |
 | Willian José | Real Sociedad | 12 | 3 | |
| 15 |  | Cédric Bakambu | Villarreal CF | 11 | 0 |
 | Wissam Ben Yedder | Séville FC | 11 | 1 | |
| Karim Benzema | Real Madrid | 11 | 0 | |
| Juanmi | Real Sociedad | 11 | 0 | |
 | Sergi Enrich | SD Eibar | 11 | 0 | |
| 20 |  | Kevin-Prince Boateng | UD Las Palmas | 10 | 0 |
| Yannick Carrasco | Atlético de Madrid | 10 | 0 | |
| Isco | Real Madrid | 10 | 0 | |
| Pedro León | SD Eibar | 10 | 1 | |
| Pablo Piatti | Espanyol Barcelona | 10 | 1 | |
| Raúl García | Athletic Bilbao | 10 | 3 | |
 | Sergio León | CA Osasuna | 10 | 1 | |
| 27 |  | Duje Čop | Sporting Gijón | 9 | 3 |
| Roberto Soriano | Villarreal CF | 9 | 0 | |
| Carlos Vela | Real Sociedad | 9 | 3 | |
| 30 | | Carmona | Sporting Gijón | 8 | 0 |
| Fernando Torres | Atlético de Madrid | 8 | 1 | |
| Pablo Sarabia | Séville FC | 8 | 1 | |
| Ivan Rakitić | FC Barcelone | 8 | 0 | |
| James Rodríguez | Real Madrid | 8 | 0 | |
| Nicola Sansone | Villarreal CF | 8 | 1 | |
 | Alexander Szymanowski | CD Leganés | 8 | 1 | |
| Xabi Prieto | Real Sociedad | 8 | 1 | |
| 38 | | Adrián | SD Eibar | 7 | 5 |
| Gareth Bale | Real Madrid | 7 | 0 | |
 | Deyverson | CD Alavés | 7 | 0 | |
| Vicente Iborra | Séville FC | 7 | 1 | |
| Jonathan Viera | UD Las Palmas | 7 | 4 | |
| Kike García | SD Eibar | 7 | 0 | |
| Kenan Kodro | CA Osasuna | 7 | 0 | |
| Muniain | Athletic Bilbao | 7 | 0 | |
| Roberto Torres | CA Osasuna | 7 | 3 | |
| Sergio Ramos | Real Madrid | 7 | 0 | |
| Franco Vázquez | Séville FC | 7 | 0 | |
| 49 | | Celso Borges | Deportivo La Coruña | 6 | 2 |
| Stevan Jovetić | Séville FC | 6 | 0 | |
| Leo Baptistão | Espanyol Barcelona | 6 | 0 | |
| Munir | FC Barcelone | 6 | 0 | |
| Pablo Fornals | Málaga CF | 6 | 0 | |
| Paco Alcácer | FC Barcelone | 6 | 0 | |
| Rafinha | FC Barcelone | 6 | 0 | |
 | Santi Mina | Valence CF | 6 | 0 | |
| Luciano Vietto | Atlético de Madrid | 6 | 0 | |
| Vitolo | Séville FC | 6 | 0 | |
| Simone Zaza | Valence CF | 6 | 0 | |
| 60 |  | Andreas Pereira | Granada CF | 5 | 0 |
| Bruno Soriano | Villarreal CF | 5 | 4 | |
| Mehdi Carcela-González | Granada CF | 5 | 0 | |
| Dani Parejo | Valence CF | 5 | 3 | |
| Gabriel | CD Leganés | 5 | 0 | |
| Guerrero | CD Leganés | 5 | 1 | |
| Ibai | Athletic Bilbao | 5 | 0 | |
| Iñaki Williams | Athletic Bilbao | 5 | 0 | |
| Joselu | Deportivo La Coruña | 5 | 0 | |
| Artem Kravets | Granada CF | 5 | 0 | |
| Mauricio Lemos | UD Las Palmas | 5 | 0 | |
| Marko Livaja | UD Las Palmas | 5 | 0 | |
| Nani | Valence CF | 5 | 1 | |
| Rodrigo | Valence CF | 5 | 0 | |
| Trigueros | Villarreal CF | 5 | 0 | |
| 75 | | Ryan Babel | Deportivo La Coruña | 4 | 0 |
| Bigas | UD Las Palmas | 4 | 0 | |
| Camacho | Málaga CF | 4 | 0 | |
| Carlos Castro | Sporting Gijón | 4 | 0 | |
| Casemiro | Real Madrid | 4 | 0 | |
| Ángel Correa | Atlético de Madrid | 4 | 0 | |
| Joaquín Correa | Séville FC | 4 | 0 | |
| Édgar Méndez | CD Alavés | 4 | 1 | |
| Nabil El Zhar | UD Las Palmas | 4 | 0 | |
| Ezequiel Garay | Valence CF | 4 | 0 | |
| John Guidetti | RC Celta | 4 | 1 | |
| Koke | Atlético de Madrid | 4 | 0 | |
| Luciano | CD Leganés | 4 | 1 | |
| Mikel San José | Athletic Bilbao | 4 | 0 | |
| Oriol Riera | CA Osasuna | 4 | 0 | |
| Adrián Ramos | Granada CF | 4 | 0 | |
| Giuseppe Rossi | RC Celta | 4 | 0 | |
| Antonio Sanabria | Betis Séville | 4 | 0 | |
| Saúl | Atlético de Madrid | 4 | 0 | |
| Soldado | Villarreal CF | 4 | 1 | |
| Tana | UD Las Palmas | 4 | 0 | |
| 96 | | Álex Alegría | Betis Séville | 3 | 0 |
| André Gomes | FC Barcelone | 3 | 0 | |
| Bebé | SD Eibar | 3 | 0 | |
| Carlos Soler | Valence CF | 3 | 0 | |
| Charles | Málaga CF | 3 | 0 | |
| Emre Çolak | Deportivo La Coruña | 3 | 0 | |
| David López | Espanyol Barcelona | 3 | 0 | |
| Douglas | FC Barcelone | 3 | 0 | |
| Filipe Luís | Atlético de Madrid | 3 | 0 | |
| Nicolás Gaitán | Atlético de Madrid | 3 | 0 | |
| Diego Godín | Atlético de Madrid | 3 | 0 | |
| Iñigo Martínez | Real Sociedad | 3 | 0 | |
| Takashi Inui | SD Eibar | 3 | 0 | |
| Iván Ramis | SD Eibar | 3 | 0 | |
| Jesé | Real Madrid | 3 | 1 | |
| Joaquín | Betis Séville | 3 | 0 | |
| Jon Bautista | Real Sociedad | 3 | 0 | |
| Jurado | Espanyol Barcelona | 3 | 0 | |
| Aleksandar Katai | CD Alavés | 3 | 0 | |
| Toni Kroos | Real Madrid | 3 | 0 | |
| Manu García | CD Alavés | 3 | 1 | |
| Marco Asensio | Real Madrid | 3 | 0 | |
| Mario Suárez | Valence CF | 3 | 0 | |
| Gabriel Mercado | Séville FC | 3 | 0 | |
| Momo | UD Las Palmas | 3 | 1 | |
| Mosquera | Deportivo La Coruña | 3 | 0 | |
| Fabián Orellana | RC Celta | 3 | 0 | |
| Hernán Pérez | Espanyol Barcelona | 3 | 0 | |
| Recio | Málaga CF | 3 | 1 | |
| Reyes | Espanyol Barcelona | 3 | 1 | |
| Christian Santos | CD Alavés | 3 | 2 | |
| Michael Santos | Málaga CF | 3 | 1 | |
| Pione Sisto | RC Celta | 3 | 0 | |
| Arda Turan | FC Barcelone | 3 | 0 | |
| Víctor Camarasa | CD Alavés | 3 | 0 | |
| Daniel Wass | RC Celta | 3 | 0 | |
| Yuri | Real Sociedad | 3 | 0 | |
| David Zurutuza | Real Sociedad | 3 | 0 | |
| 134 | | Adrián | Villarreal CF | 2 | 0 |
| Aleix Vidal | FC Barcelone | 2 | 0 | |
| Alexandre Pato | Villarreal CF | 2 | 0 | |
| Alexis | CD Alavés | 2 | 0 | |
| Sergio Araujo | UD Las Palmas | 2 | 0 | |
| Jérémie Boga | Granada CF | 2 | 0 | |
| Rafael Borré | Atlético de Madrid | 2 | 0 | |
| Bueno | Granada CF | 2 | 0 | |
| Burgui | Real Madrid | 2 | 0 | |
| Gustavo Cabral | RC Celta | 2 | 0 | |
| Felipe Caicedo | Espanyol Barcelona | 2 | 0 | |
| Canella | Sporting Gijón | 2 | 0 | |
| Dani Ceballos | Betis Séville | 2 | 0 | |
| David Timor | CD Leganés | 2 | 0 | |
| Jonathan Dos Santos | Villarreal CF | 2 | 0 | |
| Gonzalo Escalante | SD Eibar | 2 | 0 | |
| Zouhair Feddal | CD Alavés | 2 | 0 | |
| Fran Rico | Granada CF | 2 | 0 | |
| Ganso | Séville FC | 2 | 0 | |
| Mateo García | UD Las Palmas | 2 | 0 | |
| Guilherme | Deportivo La Coruña | 2 | 0 | |
| Hugo Mallo | RC Celta | 2 | 0 | |
| Iñigo Lekue | Athletic Bilbao | 2 | 0 | |
| Isaac Cuenca | Granada CF | 2 | 0 | |
| Javi Ontiveros | Málaga CF | 2 | 0 | |
| Jony | Málaga CF | 2 | 1 | |
| Jozabed | RC Celta | 2 | 0 | |
| Juankar | Málaga CF | 2 | 0 | |
| Juanpi | Málaga CF | 2 | 0 | |
| Gaël Kakuta | Deportivo La Coruña | 2 | 0 | |
| Nenad Krstičić | CD Alavés | 2 | 0 | |
| Laguardia | CD Alavés | 2 | 0 | |
| Aymeric Laporte | Athletic Bilbao | 2 | 0 | |
| Llorente | Málaga CF | 2 | 0 | |
| Lombán | Granada CF | 2 | 0 | |
| Lucas Vázquez | Real Madrid | 2 | 0 | |
| Aïssa Mandi | Betis Séville | 2 | 0 | |
| Eliaquim Mangala | Valence CF | 2 | 0 | |
| Marcelo | Real Madrid | 2 | 0 | |
| Jonas Martin | Betis Séville | 2 | 0 | |
| Martín Montoya | FC Barcelone | 2 | 0 | |
| Medrán | Valence CF | 2 | 0 | |
| Mikel Oyarzabal | Real Sociedad | 2 | 0 | |
| Moi Gómez | Sporting Gijón | 2 | 1 | |
| Jhon Mondragón | CA Osasuna | 2 | 0 | |
| Nacho | Real Madrid | 2 | 0 | |
| Nacho Cases | Sporting Gijón | 2 | 0 | |
| Samir Nasri | Séville FC | 2 | 0 | |
| Marc Navarro | Espanyol Barcelona | 2 | 0 | |
| Steven Nzonzi | Séville FC | 2 | 0 | |
| Pepe | Real Madrid | 2 | 0 | |
| Cristiano Piccini | Betis Séville | 2 | 0 | |
| Piqué | FC Barcelone | 2 | 0 | |
| Ezequiel Ponce | Granada CF | 2 | 0 | |
| Rafa Navarro | Betis Séville | 2 | 0 | |
| Robert Ibáñez | Valence CF | 2 | 0 | |
| Facundo Roncaglia | RC Celta | 2 | 0 | |
| Rubén Sobrino | CD Alavés | 2 | 0 | |
| Samu Castillejo | Villarreal CF | 2 | 0 | |
| Sergio Álvarez | Sporting Gijón | 2 | 0 | |
| Lacina Traoré | Sporting Gijón | 2 | 0 | |
| Unai López | Athletic Bilbao | 2 | 0 | |
| Vicente Gómez | UD Las Palmas | 2 | 0 | |
| Víctor | Sporting Gijón | 2 | 0 | |
| Viguera | Athletic Bilbao | 2 | 0 | |
| 199 | | Álex Berenguer | CA Osasuna | 1 | 0 |
| Álex Bergantiños | Deportivo La Coruña | 1 | 0 | |
| Álvaro Cejudo | Betis Séville | 1 | 0 | |
| Álvaro González | Espanyol Barcelona | 1 | 0 | |
| Antonio Luna | SD Eibar | 1 | 0 | |
| Jean-Sylvain Babin | Granada CF | 1 | 0 | |
| Zakaria Bakkali | Valence CF | 1 | 0 | |
| Balenziaga | Athletic Bilbao | 1 | 0 | |
| Claudio Beauvue | RC Celta | 1 | 0 | |
| Beñat | Athletic Bilbao | 1 | 0 | |
| Théo Bongonda | RC Celta | 1 | 0 | |
| Darko Brašanac | Betis Séville | 1 | 0 | |
| Bruno | Betis Séville | 1 | 0 | |
| Carles Gil | Deportivo La Coruña | 1 | 0 | |
| Carlos Clerc | CA Osasuna | 1 | 0 | |
| Carlos Fernández | Séville FC | 1 | 0 | |
| Gonzalo Castro | Málaga CF | 1 | 0 | |
| Goran Čaušić | CA Osasuna | 1 | 0 | |
| Pape Cheikh Diop | RC Celta | 1 | 0 | |
| Dani García | SD Eibar | 1 | 0 | |
| Danilo | Real Madrid | 1 | 0 | |
| David García | UD Las Palmas | 1 | 0 | |
| David García | CA Osasuna | 1 | 0 | |
| De Marcos | Athletic Bilbao | 1 | 0 | |
| Denis Suárez | FC Barcelone | 1 | 0 | |
| Marcelo Díaz | RC Celta | 1 | 0 | |
| Diego Rico | CD Leganés | 1 | 0 | |
| Duda | Málaga CF | 1 | 0 | |
| Riza Durmisi | Betis Séville | 1 | 0 | |
| Elderson Echiéjilé | Sporting Gijón | 1 | 0 | |
| Youssef En-Nesyri | Málaga CF | 1 | 0 | |
| Fontàs | RC Celta | 1 | 0 | |
| Fran Mérida | CA Osasuna | 1 | 0 | |
| Gayà | Valence CF | 1 | 0 | |
| Felipe Gutiérrez | Betis Séville | 1 | 0 | |
| Pablo Hernández | RC Celta | 1 | 0 | |
| Theo Hernández | Atlético de Madrid | 1 | 0 | |
| Andrew Hjulsager | RC Celta | 1 | 0 | |
| Illarramendi | Real Sociedad | 1 | 0 | |
| Sverrir Ingason | Granada CF | 1 | 0 | |
| Jaume Costa | Villarreal CF | 1 | 0 | |
| Javi Fuego | Espanyol Barcelona | 1 | 0 | |
| João Cancelo | Valence CF | 1 | 0 | |
| Jordi Alba | FC Barcelone | 1 | 0 | |
| Hiroshi Kiyotake | Séville FC | 1 | 0 | |
| Mateo Kovačić | Real Madrid | 1 | 0 | |
| Florian Lejeune | SD Eibar | 1 | 0 | |
| Lemos | RC Celta | 1 | 0 | |
| Lucas Pérez | Deportivo La Coruña | 1 | 1 | |
| Luis Hernández | Málaga CF | 1 | 0 | |
| Darwin Machís | Granada CF | 1 | 0 | |
| Martín Mantovani | CD Leganés | 1 | 0 | |
| Mariano | Real Madrid | 1 | 0 | |
| Markel Susaeta | Athletic Bilbao | 1 | 0 | |
| Javier Mascherano | FC Barcelone | 1 | 1 | |
| Jérémy Mathieu | FC Barcelone | 1 | 0 | |
| Miguel Flaño | CA Osasuna | 1 | 0 | |
| Mikel Rico | Athletic Bilbao | 1 | 0 | |
| Luka Modrić | Real Madrid | 1 | 0 | |
| Nano Mesa | SD Eibar | 1 | 0 | |
| Olavide | CA Osasuna | 1 | 0 | |
| Pablo Insua | Deportivo La Coruña | 1 | 0 | |
| Nicolás Pareja | Séville FC | 1 | 0 | |
| Thomas Partey | Atlético de Madrid | 1 | 0 | |
| Petros | Betis Séville | 1 | 0 | |
| Germán Pezzella | Betis Séville | 1 | 0 | |
| Nemanja Radoja | RC Celta | 1 | 0 | |
| Raúl Albentosa | Deportivo La Coruña | 1 | 0 | |
| Raúl Navas | Real Sociedad | 1 | 0 | |
| Diego Reyes | Espanyol Barcelona | 1 | 0 | |
| Rodrigo Ely | CD Alavés | 1 | 0 | |
| Roque Mesa | UD Las Palmas | 1 | 0 | |
| Roberto Rosales | Málaga CF | 1 | 0 | |
| Rubén Pardo | Betis Séville | 1 | 0 | |
| Rubén Peña | SD Eibar | 1 | 0 | |
| Sabin | Athletic Bilbao | 1 | 0 | |
| Stefan Savić | Atlético de Madrid | 1 | 0 | |
| Sidnei | Deportivo La Coruña | 1 | 0 | |
| Dimitrios Siovas | CD Leganés | 1 | 0 | |
| Tiago | Atlético de Madrid | 1 | 0 | |
| Toquero | CD Alavés | 1 | 0 | |
| Samuel Umtiti | FC Barcelone | 1 | 0 | |
| Raphaël Varane | Real Madrid | 1 | 0 | |
| Vesga | Athletic Bilbao | 1 | 0 | |
| Víctor Díaz | CD Leganés | 1 | 0 | |
| Víctor Ruiz | Villarreal CF | 1 | 0 | |
| Víctor Sánchez | Espanyol Barcelona | 1 | 0 | |
| Mubarak Wakaso | Granada CF | 1 | 0 |
