| # | Nom | Équipe | Buts | Pén | |
|---|---|---|---|---|---|
| 1 |  | Lionel Messi | FC Barcelone | 25 | 5 |
| 2 |  | Karim Benzema | Real Madrid | 21 | 5 |
| 3 |  | Gerard Moreno | Villarreal CF | 18 | 1 |
| 4 | | Luis Suárez | FC Barcelone | 16 | 1 |
| 5 |  | Raúl García | Athletic Bilbao | 15 | 7 |
| 6 |  | Iago Aspas | RC Celta | 14 | 5 |
 | Lucas Ocampos | Séville FC | 14 | 5 | |
| 8 |  | Ante Budimir | RCD Mallorca | 13 | 2 |
| 9 |  | Álvaro Morata | Atlético de Madrid | 12 | 2 |
| 10 |  | Jaime Mata | Getafe CF | 11 | 3 |
 | Joselu | CD Alavés | 11 | 1 | |
| Lucas Pérez | CD Alavés | 11 | 5 | |
 | Roger Martí | Levante UD | 11 | 4 | |
| Santi Cazorla | Villarreal CF | 11 | 8 | |
| Sergio Ramos | Real Madrid | 11 | 6 | |
 | Willian José | Real Sociedad | 11 | 0 | |
| 17 | | Ángel | Getafe CF | 10 | 1 |
 | Carlos Fernández | Granada CF | 10 | 1 | |
 | Maximiliano Gómez | Valence CF | 10 | 0 | |
| Mikel Oyarzabal | Real Sociedad | 10 | 4 | |
 | Loren Morón | Betis Séville | 10 | 0 | |
| 22 |  | Chimy Ávila | CA Osasuna | 9 | 0 |
| Antoine Griezmann | Atlético de Madrid | 9 | 0 | |
| Alexander Isak | Real Sociedad | 9 | 0 | |
 | Óscar | CD Leganés | 9 | 2 | |
| 26 | | Borja Mayoral | Levante UD | 8 | 0 |
| Dani Parejo | Valence CF | 8 | 5 | |
| Youssef En-Nesyri | Séville FC | 8 | 0 | |
| Joaquín | Betis Séville | 8 | 2 | |
 | Fabián Orellana | SD Eibar | 8 | 4 | |
| Rubén García | CA Osasuna | 8 | 1 | |
 | Sergi Guardiola | Real Valladolid | 8 | 0 | |
| Arturo Vidal | FC Barcelone | 8 | 0 | |
| 34 | | Ansu Fati | FC Barcelone | 7 | 0 |
| Enis Bardhi | Levante UD | 7 | 0 | |
| Martin Braithwaite | FC Barcelone | 7 | 0 | |
| Nabil Fekir | Betis Séville | 7 | 1 | |
| Darwin Machís | Granada CF | 7 | 1 | |
| Portu | Real Sociedad | 7 | 0 | |
| Puertas | Granada CF | 7 | 0 | |
| Roberto Torres | CA Osasuna | 7 | 5 | |
| Soldado | Granada CF | 7 | 1 | |
| 43 | | Charles | SD Eibar | 6 | 1 |
| Luuk de Jong | Séville FC | 6 | 0 | |
| Kevin Gameiro | Valence CF | 6 | 0 | |
| Iñaki Williams | Athletic Bilbao | 6 | 1 | |
| João Félix | Atlético de Madrid | 6 | 0 | |
| Santi Mina | RC Celta | 6 | 0 | |
| Saúl Ñíguez | Atlético de Madrid | 6 | 2 | |
| Sergio Canales | Betis Séville | 6 | 3 | |
| Karl Toko Ekambi | Villarreal CF | 6 | 0 | |
| Enes Ünal | Real Valladolid | 6 | 2 | |
| 53 | | Ángel Correa | Atlético de Madrid | 5 | 0 |
| Dani Rodríguez | RCD Mallorca | 5 | 1 | |
| Diego Costa | Atlético de Madrid | 5 | 2 | |
| Cucho Hernández | RCD Mallorca | 5 | 0 | |
| Jorge Molina | Getafe CF | 5 | 2 | |
| Kike García | SD Eibar | 5 | 0 | |
| Mikel Merino | Real Sociedad | 5 | 0 | |
| Moi Gómez | Villarreal CF | 5 | 0 | |
| Muniain | Athletic Bilbao | 5 | 0 | |
| Munir | Séville FC | 5 | 0 | |
| Nolito | RC Celta | 5 | 1 | |
| Rubén Rochina | Levante UD | 5 | 0 | |
| Salva Sevilla | RCD Mallorca | 5 | 2 | |
| 66 | | Casemiro | Real Madrid | 4 | 0 |
 | David López | Espanyol Barcelona | 4 | 0 | |
| Edu Expósito | SD Eibar | 4 | 1 | |
| Ferran Torres | Valence CF | 4 | 0 | |
| José Morales | Levante UD | 4 | 0 | |
| Lago Júnior | RCD Mallorca | 4 | 3 | |
| Koke | Atlético de Madrid | 4 | 0 | |
| Toni Kroos | Real Madrid | 4 | 0 | |
| Takefusa Kubo | RCD Mallorca | 4 | 0 | |
| Óscar Plano | Real Valladolid | 4 | 0 | |
| Martin Ødegaard | Real Madrid | 4 | 0 | |
| Paco Alcácer | Villarreal CF | 4 | 0 | |
| Rafinha | RC Celta | 4 | 0 | |
| Raúl de Tomás | Espanyol Barcelona | 4 | 1 | |
| Rodrigo | Valence CF | 4 | 0 | |
| Lei Wu | Espanyol Barcelona | 4 | 0 | |
| 82 | | Aridane | CA Osasuna | 3 | 0 |
| Arthur | FC Barcelone | 3 | 0 | |
| Éver Banega | Séville FC | 3 | 2 | |
| Bigas | SD Eibar | 3 | 0 | |
| Borja Iglesias | Espanyol Barcelona | 3 | 0 | |
| Capa | Athletic Bilbao | 3 | 0 | |
| Samuel Chukwueze | Villarreal CF | 3 | 0 | |
| David Timor | Getafe CF | 3 | 0 | |
| Domingos Duarte | Granada CF | 3 | 0 | |
| Emerson Royal | FC Barcelone | 3 | 0 | |
| Enric Gallego | CA Osasuna | 3 | 0 | |
| Bernardo Espinosa | Espanyol Barcelona | 3 | 0 | |
| Adnan Januzaj | Real Sociedad | 3 | 0 | |
| Marc Bartra | Betis Séville | 3 | 0 | |
| Marco Asensio | Real Madrid | 3 | 0 | |
| Marcos Llorente | Atlético de Madrid | 3 | 0 | |
| Luka Modrić | Real Madrid | 3 | 0 | |
| Óliver Torres | Séville FC | 3 | 0 | |
| Thomas Partey | Atlético de Madrid | 3 | 0 | |
| Sandro | Real Valladolid | 3 | 0 | |
| Vadillo | Granada CF | 3 | 1 | |
| Franco Vázquez | Séville FC | 3 | 0 | |
| Villalibre | Athletic Bilbao | 3 | 0 | |
| Vinícius Junior | Real Madrid | 3 | 0 | |
| Vitolo | Atlético de Madrid | 3 | 0 | |
| 107 | | Adrián | CA Osasuna | 2 | 1 |
| Adrián Embarba | Espanyol Barcelona | 2 | 1 | |
| Alcaraz | Real Valladolid | 2 | 0 | |
| Aleix Vidal | CD Alavés | 2 | 0 | |
| Frank Anguissa | Villarreal CF | 2 | 0 | |
| Roger Assalé | CD Leganés | 2 | 0 | |
| Ramon Azeez | Granada CF | 2 | 0 | |
| Carlos Bacca | Villarreal CF | 2 | 0 | |
| Gareth Bale | Real Madrid | 2 | 0 | |
| Busquets | FC Barcelone | 2 | 0 | |
| Leandro Cabrera | Espanyol Barcelona | 2 | 0 | |
| Carlos Soler | Valence CF | 2 | 0 | |
| Cristian Tello | Betis Séville | 2 | 0 | |
| Pablo de Blasis | SD Eibar | 2 | 1 | |
| Frenkie de Jong | FC Barcelone | 2 | 0 | |
| Diego Carlos | Séville FC | 2 | 0 | |
| Fede Vico | Granada CF | 2 | 1 | |
| Fernando | Séville FC | 2 | 0 | |
| Germán | Granada CF | 2 | 0 | |
| Gonçalo Guedes | Valence CF | 2 | 0 | |
| Gonzalo Melero | Levante UD | 2 | 1 | |
| Hernâni | Levante UD | 2 | 0 | |
| Yangel Herrera | Granada CF | 2 | 0 | |
| Iñigo Pérez | CA Osasuna | 2 | 0 | |
| Takashi Inui | Betis Séville | 2 | 0 | |
| Javi Ontiveros | Villarreal CF | 2 | 0 | |
| Joan Jordán | Séville FC | 2 | 0 | |
| Joaquín | Real Valladolid | 2 | 0 | |
| Jordi Alba | FC Barcelone | 2 | 0 | |
| José Arnáiz | CA Osasuna | 2 | 0 | |
| José Campaña | Levante UD | 2 | 0 | |
| Luka Jović | Real Madrid | 2 | 0 | |
| Kiko Olivas | Real Valladolid | 2 | 0 | |
| Kang-in Lee | Valence CF | 2 | 0 | |
| Clément Lenglet | FC Barcelone | 2 | 0 | |
| Lucas Vázquez | Real Madrid | 2 | 0 | |
| Nemanja Maksimović | Getafe CF | 2 | 0 | |
| Manu Vallejo | Valence CF | 2 | 0 | |
| Marc Roca | Espanyol Barcelona | 2 | 2 | |
| Montoro | Granada CF | 2 | 0 | |
| Nacho Monreal | Real Sociedad | 2 | 0 | |
| Allan Nyom | Getafe CF | 2 | 0 | |
| Oier | CA Osasuna | 2 | 0 | |
| Pau Torres | Villarreal CF | 2 | 0 | |
| Reguilón | Real Madrid | 2 | 0 | |
| Rodrigo Ely | CD Alavés | 2 | 0 | |
| Rodrygo | Real Madrid | 2 | 0 | |
| Rubén Peña | SD Eibar | 2 | 0 | |
| Sergi Darder | Espanyol Barcelona | 2 | 0 | |
| Pione Sisto | RC Celta | 2 | 0 | |
| Fedor Smolov | RC Celta | 2 | 0 | |
| Trigueros | Villarreal CF | 2 | 1 | |
| Federico Valverde | Real Madrid | 2 | 0 | |
| Raphaël Varane | Real Madrid | 2 | 0 | |
| Yuri | Athletic Bilbao | 2 | 0 | |
| 162 | | Adrià Pedrosa | Espanyol Barcelona | 1 | 0 |
| Aduriz | Athletic Bilbao | 1 | 0 | |
| Lumor Agbenyenu | RCD Mallorca | 1 | 0 | |
| Alejandro Pozo | RCD Mallorca | 1 | 0 | |
| Ander Barrenetxea | Real Sociedad | 1 | 0 | |
| Antoñín | Granada CF | 1 | 0 | |
| Mauro Arambarri | Getafe CF | 1 | 0 | |
| Néstor Araujo | RC Celta | 1 | 0 | |
| Arbilla | SD Eibar | 1 | 0 | |
| Borja Sainz | CD Alavés | 1 | 0 | |
| Bryan Gil | Séville FC | 1 | 0 | |
| Esteban Burgos | SD Eibar | 1 | 0 | |
| Oliver Burke | CD Alavés | 1 | 0 | |
| Jonathan Calleri | Espanyol Barcelona | 1 | 0 | |
| Carles Aleñá | FC Barcelone | 1 | 0 | |
| Carles Pérez | FC Barcelone | 1 | 0 | |
| Yannick Carrasco | Atlético de Madrid | 1 | 0 | |
| Guido Carrillo | CD Leganés | 1 | 0 | |
| Denis Cheryshev | Valence CF | 1 | 0 | |
| Coke | Levante UD | 1 | 0 | |
| Córdoba | Athletic Bilbao | 1 | 0 | |
| Cote | SD Eibar | 1 | 0 | |
| Cucurella | FC Barcelone | 1 | 0 | |
| Dani Carvajal | Real Madrid | 1 | 0 | |
| Ousmane Dembélé | FC Barcelone | 1 | 0 | |
| Denis Suárez | RC Celta | 1 | 0 | |
| Pape Diop | SD Eibar | 1 | 0 | |
| Édgar Méndez | CD Alavés | 1 | 0 | |
| Pervis Estupiñán | CA Osasuna | 1 | 0 | |
| Peter Etebo | Getafe CF | 1 | 0 | |
| Zouhair Feddal | Betis Séville | 1 | 0 | |
| Felipe Monteiro | Atlético de Madrid | 1 | 0 | |
| Fer Niño | Villarreal CF | 1 | 0 | |
| Gabriel Fernández | RC Celta | 1 | 0 | |
| Facundo Ferreyra | Espanyol Barcelona | 1 | 0 | |
| Junior Firpo | FC Barcelone | 1 | 0 | |
| Dimitri Foulquier | Granada CF | 1 | 0 | |
| Fran Beltrán | RC Celta | 1 | 0 | |
| Gabriel Paulista | Valence CF | 1 | 0 | |
| Granero | Espanyol Barcelona | 1 | 0 | |
| Guerrero | CD Leganés | 1 | 0 | |
| Eden Hazard | Real Madrid | 1 | 0 | |
| Javier Hernández | Séville FC | 1 | 0 | |
| Hugo Duro | Getafe CF | 1 | 0 | |
| Iborra | Villarreal CF | 1 | 0 | |
| Iker Losada | RC Celta | 1 | 0 | |
| Iñigo Martínez | Athletic Bilbao | 1 | 0 | |
| Isco | Real Madrid | 1 | 0 | |
| Iván Ramis | SD Eibar | 1 | 0 | |
| Jason | Getafe CF | 1 | 0 | |
| Javier Avilés | CD Leganés | 1 | 0 | |
| Juan Villar | CA Osasuna | 1 | 1 | |
| Juanmi | Betis Séville | 1 | 0 | |
| Kenedy | Getafe CF | 1 | 0 | |
| Kenan Kodro | Athletic Bilbao | 1 | 0 | |
| Geoffrey Kondogbia | Valence CF | 1 | 0 | |
| Jules Koundé | Séville FC | 1 | 0 | |
| Laguardia | CD Alavés | 1 | 0 | |
| Robin Le Normand | Real Sociedad | 1 | 0 | |
| Llorente | Real Sociedad | 1 | 0 | |
| Lisandro Magallán | CD Alavés | 1 | 0 | |
| Marc Cardona | CA Osasuna | 1 | 0 | |
| Marcelo | Real Madrid | 1 | 0 | |
| Mariano | Real Madrid | 1 | 0 | |
| Martín | CD Alavés | 1 | 0 | |
| Ferland Mendy | Real Madrid | 1 | 0 | |
| Míchel | Real Valladolid | 1 | 1 | |
| Moncayola | CA Osasuna | 1 | 0 | |
| Jeison Murillo | RC Celta | 1 | 0 | |
| Nacho | Real Madrid | 1 | 0 | |
| Nélson Semedo | FC Barcelone | 1 | 0 | |
| Oihan Sancet | Athletic Bilbao | 1 | 0 | |
| Lucas Olaza | RC Celta | 1 | 0 | |
| Kenneth Omeruo | CD Leganés | 1 | 0 | |
| Pablo Hervías | Real Valladolid | 1 | 0 | |
| Paulo Oliveira | SD Eibar | 1 | 0 | |
| Pedraza | Betis Séville | 1 | 0 | |
| Pedro León | SD Eibar | 1 | 0 | |
| Pere Pons | CD Alavés | 1 | 0 | |
| Pina | CD Alavés | 1 | 0 | |
| Piqué | FC Barcelone | 1 | 0 | |
| Nemanja Radoja | Levante UD | 1 | 0 | |
| Raíllo | RCD Mallorca | 1 | 0 | |
| Ivan Rakitić | FC Barcelone | 1 | 0 | |
| Raúl Albiol | Villarreal CF | 1 | 0 | |
| Renan Lodi | Atlético de Madrid | 1 | 0 | |
| Rober Ibáñez | CA Osasuna | 1 | 0 | |
| Kévin Rodrigues | Real Sociedad | 1 | 0 | |
| Guido Rodríguez | Betis Séville | 1 | 0 | |
| James Rodríguez | Real Madrid | 1 | 0 | |
| Facundo Roncaglia | CA Osasuna | 1 | 0 | |
| Roque Mesa | Séville FC | 1 | 0 | |
| Rubén Pérez | CD Leganés | 1 | 1 | |
| Rubén Sobrino | Valence CF | 1 | 0 | |
| Mohammed Salisu | Real Valladolid | 1 | 0 | |
| Sergi Enrich | SD Eibar | 1 | 0 | |
| Sergi Roberto | FC Barcelone | 1 | 0 | |
| Sergio Escudero | Séville FC | 1 | 0 | |
| Sergio León | Levante UD | 1 | 0 | |
| Sergio Postigo | Levante UD | 1 | 0 | |
| Sidnei | Betis Séville | 1 | 0 | |
| Jonathan Silva | CD Leganés | 1 | 0 | |
| Damián Suárez | Getafe CF | 1 | 0 | |
| Suso | Séville FC | 1 | 0 | |
| Toni Lato | CA Osasuna | 1 | 0 | |
| Unai García | CA Osasuna | 1 | 0 | |
| Unai López | Athletic Bilbao | 1 | 0 | |
| Víctor Díaz | Granada CF | 1 | 0 | |
| Víctor García | Real Valladolid | 1 | 0 | |
| Daniel Wass | Valence CF | 1 | 0 |
